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Proteins/UNIPROT:Q15758
Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system. Part of transport systems for D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels. Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development..
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114..
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus..
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses..
Function from UniProtKB (Q15758), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 6 · transported by
6 compounds
6 compounds.
0 reported routes6 assembled routes
278 statements
278 statements · 7 reference databases · Subject: SLC1A5 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
49 reactions
L-alanine+sodium(1+)L-alanine+sodium(1+)
Transported by SLC6A15 or SLC1A5 or SLC38A1 or SLC1A4 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05305CC BY 4.0Reference data
10 names
Resolves to: SLC1A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05308CC BY 4.0Reference data
L-alanine+L-glutamine+sodium(1+)L-alanine+L-glutamine+sodium(1+)
Transported by SLC7A6 or SLC1A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05603CC BY 4.0Reference data
L-alanine+sodium(1+)+L-seryl residueL-alanine+sodium(1+)+L-seryl residue
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05604CC BY 4.0Reference data
L-alanine+L-cysteine+sodium(1+)L-alanine+L-cysteine+sodium(1+)
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05609CC BY 4.0Reference data
L-alanine+L-asparagine+sodium(1+)L-alanine+L-asparagine+sodium(1+)
Transported by SLC1A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05612CC BY 4.0Reference data
L-alanine+sodium(1+)+CHEBI:16857L-alanine+sodium(1+)+CHEBI:16857
Transported by SLC7A6 or SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05614CC BY 4.0Reference data
L-alanine+L-glutamine+sodium(1+)L-alanine+L-glutamine+sodium(1+)
Transported by SLC1A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05618CC BY 4.0Reference data
L-glutamine+sodium(1+)+L-seryl residueL-glutamine+sodium(1+)+L-seryl residue
Transported by SLC7A6 or SLC1A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05619CC BY 4.0Reference data
L-cysteine+L-glutamine+sodium(1+)L-cysteine+L-glutamine+sodium(1+)
Transported by SLC7A6 or SLC1A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05624CC BY 4.0Reference data
L-asparagine+L-glutamine+sodium(1+)L-asparagine+L-glutamine+sodium(1+)
Transported by SLC1A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05627CC BY 4.0Reference data
L-glutamine+sodium(1+)+CHEBI:16857L-glutamine+sodium(1+)+CHEBI:16857
Transported by SLC7A6 or SLC1A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05629CC BY 4.0Reference data