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Proteins/UNIPROT:P46597
[Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine)..
[Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity..
[Isoform 3]: Does not show Acetylserotonin O-methyltransferase activity..
Function from UniProtKB (P46597), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
12 statements
12 statements · 4 reference databases · Subject: ASMT · Sources: Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
N-acetylserotonin+S-adenosyl-L-methionineproton+melatonin+CHEBI:16680
Catalysed by ASMT
Reaction pageLeft to rightBalancedEC 2.1.1.4cytosol
Human-GEM MAR04547CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetate+S-adenosyl-L-methionineMAM01112c+proton+CHEBI:16680
Catalysed by ASMT
2 names
Resolves to: ASMT
Human-GEM MAR04564CC BY 4.0Reference data
N-acetylserotonin+S-adenosyl-L-methioninemelatonin+S-adenosyl-L-homocysteine+hydron
Catalysed by ASMT
Reaction pageRight to leftBalanced
Rhea RHEA:15573CC BY 4.0Reference data