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Proteins/UNIPROT:Q6VVX0
A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..
Function from UniProtKB (Q6VVX0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · metabolized by
2 compounds
2 compounds.
0 reported routes2 assembled routes
2 rows
23 statements
23 statements · 7 reference databases · Subject: CYP2R1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
proton+NADPH(4-)+dioxygen+CHEBI:283119calcidiol+water+NADP(3-)
Catalysed by CYP2R1
Reaction pageLeft to rightBalancedEC 1.14.14.24cytosol
Human-GEM MAR02115CC BY 4.0Reference data
calciol+reduced [NADPH--hemoprotein reductase]+dioxygencalcidiol+
1 name
Resolves to: CYP2R1
Catalysed by CYP2R1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32903CC BY 4.0Reference data
vitamin D2+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:86319+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2R1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46580CC BY 4.0Reference data
CHEBI:4712+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:86320+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2R1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46584CC BY 4.0Reference data
alfacalcidol+reduced [NADPH--hemoprotein reductase]+dioxygencalcitriol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2R1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49272CC BY 4.0Reference data