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Proteins/UNIPROT:P00966
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues..
Function from UniProtKB (P00966), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
3 rows
323 statements
323 statements · 8 reference databases · Subject: ASS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
2 reactions
L-aspartate+ATP+L-citrullineAMP+2-(N(omega)-L-arginino)succinate+proton+diphosphate(3-)
Catalysed by ASS1
Reaction pageLeft to rightBalancedEC 6.3.4.5cytosol
Human-GEM MAR03811CC BY 4.0Reference data
L-citrulline+L-aspartate+ATP(4-)2-(N(omega)-L-arginino)succinate
2 names
Resolves to: ASS1
Catalysed by ASS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:10932CC BY 4.0Reference data