Loading the page.
Proteins/UNIPROT:P43007
Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way. Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-)..
Function from UniProtKB (P43007), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 5 · transported by
5 compounds
5 compounds.
0 reported routes5 assembled routes
1 row
439 statements
439 statements · 7 reference databases · Subject: SLC1A4 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
35 reactions
L-alanine+sodium(1+)L-alanine+sodium(1+)
Transported by SLC6A15 or SLC1A5 or SLC38A1 or SLC1A4 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05305CC BY 4.0Reference data
5 names
Resolves to: SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05604CC BY 4.0Reference data
L-alanine+L-cysteine+sodium(1+)L-alanine+L-cysteine+sodium(1+)
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05609CC BY 4.0Reference data
L-alanine+sodium(1+)+CHEBI:16857L-alanine+sodium(1+)+CHEBI:16857
Transported by SLC7A6 or SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05614CC BY 4.0Reference data
L-alanine+sodium(1+)+L-seryl residueL-alanine+sodium(1+)+L-seryl residue
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05633CC BY 4.0Reference data
L-cysteine+sodium(1+)+L-seryl residueL-cysteine+sodium(1+)+L-seryl residue
Transported by SLC7A6 or SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05639CC BY 4.0Reference data
sodium(1+)+L-seryl residue+CHEBI:16857sodium(1+)+L-seryl residue+CHEBI:16857
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05644CC BY 4.0Reference data
L-alanine+L-cysteine+sodium(1+)L-alanine+L-cysteine+sodium(1+)
Transported by SLC1A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05708CC BY 4.0Reference data
L-cysteine+L-glutamine+sodium(1+)L-cysteine+L-glutamine+sodium(1+)
Transported by SLC7A6 or SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05709CC BY 4.0Reference data
L-cysteine+sodium(1+)+L-seryl residueL-cysteine+sodium(1+)+L-seryl residue
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05710CC BY 4.0Reference data
L-asparagine+L-cysteine+sodium(1+)L-asparagine+L-cysteine+sodium(1+)
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05717CC BY 4.0Reference data
L-cysteine+sodium(1+)+CHEBI:16857L-cysteine+sodium(1+)+CHEBI:16857
Transported by SLC1A5 or SLC1A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05719CC BY 4.0Reference data