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Proteins/UNIPROT:Q6NUK1
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates..
Function from UniProtKB (Q6NUK1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
118 statements
118 statements · 4 reference databases · Subject: SLC25A24 · Sources: Hetionet, Human Protein Atlas, Rhea, WikiPathways
12 reactions
magnesium(2+)+hydrogenphosphate+ATP(4-)magnesium(2+)+hydrogenphosphate+ATP(4-)
Transported by SLC25A25 or SLC25A24 or SLC25A41 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:65840CC BY 4.0Reference data
8 names
Resolves to: SLC25A24
Reaction pageDirection not assertedBalanced
Rhea RHEA:65844CC BY 4.0Reference data
AMP+hydrogenphosphateAMP+hydrogenphosphate
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:70259CC BY 4.0Reference data
hydrogenphosphate+ATP(4-)+2hydronhydrogenphosphate+ATP(4-)+2hydron
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:72035CC BY 4.0Reference data
Transported by SLC25A24 or SLC25A42 or SLC25A23 or SLC25A31
Reaction pageReversibleBalanced
Rhea RHEA:72855CC BY 4.0Reference data
magnesium(2+)+ADP(3-)+ATP(4-)+hydronmagnesium(2+)+ADP(3-)+ATP(4-)+hydron
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73659CC BY 4.0Reference data
ADP(3-)+diphosphate(3-)ADP(3-)+diphosphate(3-)
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73671CC BY 4.0Reference data
CHEBI:58245+ADP(3-)+hydronCHEBI:58245+ADP(3-)+hydron
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73675CC BY 4.0Reference data
CHEBI:60880+ADP(3-)+hydronCHEBI:60880+ADP(3-)+hydron
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73679CC BY 4.0Reference data
CHEBI:58245+hydrogenphosphateCHEBI:58245+hydrogenphosphate
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73687CC BY 4.0Reference data
CHEBI:60880+hydrogenphosphateCHEBI:60880+hydrogenphosphate
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73691CC BY 4.0Reference data
dADP+hydrogenphosphate+hydrondADP+hydrogenphosphate+hydron
Transported by SLC25A24 or SLC25A23
Reaction pageDirection not assertedBalanced
Rhea RHEA:73695CC BY 4.0Reference data