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Proteins/UNIPROT:P50443
Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions. Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity)..
Function from UniProtKB (P50443), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
6 rows
79 statements
79 statements · 7 reference databases · Subject: SLC26A2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
hydrogencarbonate+sulfatehydrogencarbonate+sulfate
Transported by SLC26A8 or SLC26A1 or SLC26A2 or SLC26A9 or SLC26A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01914CC BY 4.0Reference data
4 names
Resolves to: SLC26A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR04946CC BY 4.0Reference data
chlorine(.)+2hydrogencarbonatechlorine(.)+2hydrogencarbonate
Transported by SLC26A8 or SLC26A7 or SLC26A2 or SLC26A9
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06534CC BY 4.0Reference data
2hydrogencarbonate+oxalic acid2hydrogencarbonate+oxalic acid
Transported by SLC26A3 or SLC26A1 or SLC26A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07902CC BY 4.0Reference data
2proton+sulfate2proton+sulfate
Transported by SLC26A1 or SLC26A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09590CC BY 4.0Reference data
oxalate+sulfateoxalate+sulfate
Transported by SLC25A14 or SLC26A2 or SLC25A30 or SLC26A6 or SLC26A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72275CC BY 4.0Reference data
iodide+chlorideiodide+chloride
Transported by SLC26A4 or SLC26A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72379CC BY 4.0Reference data
sulfate+2chloridesulfate+2chloride
Transported by SLC26A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:75091CC BY 4.0Reference data
oxalate+2chlorideoxalate+2chloride
Transported by SLC26A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:75095CC BY 4.0Reference data
bromide+chloridebromide+chloride
Transported by SLC26A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:75335CC BY 4.0Reference data
nitrate+chloridenitrate+chloride
Transported by SLC26A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:75339CC BY 4.0Reference data