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Proteins/UNIPROT:P29475
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR..
Function from UniProtKB (P29475), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
98 statements
98 statements · 8 reference databases · Subject: NOS1 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
L-arginine+2NADPH(4-)+2dioxygenL-citrulline+2water+2NADP(3-)+nitric oxide
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageLeft to rightUnbalancedEC 1.14.13.39cytosol
Human-GEM MAR02023CC BY 4.0Reference data
9 names
Resolves to: NOS1
Reaction pageLeft to rightBalancedEC 1.14.13.39cytosol
Human-GEM MAR03993CC BY 4.0Reference data
L-arginine+proton+NADPH(4-)+dioxygenwater+N(5)-[(Z)-amino(hydroxyimino)methyl]ornithine+NADP(3-)
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageReversibleBalancedEC 1.14.13.39cytosol
Human-GEM MAR04190CC BY 4.0Reference data
2L-arginine+3NADPH(4-)+4dioxygen+hydron2L-citrulline+2nitric oxide+3NADP(3-)+4water
Catalysed by NOS3 or NOS1 or NOS2
Reaction pageLeft to rightBalanced
Rhea RHEA:19897CC BY 4.0Reference data