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Proteins/UNIPROT:P06732
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
Function from UniProtKB (P06732), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
52 statements
52 statements · 7 reference databases · Subject: CKM · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+creatineADP+N-phosphocreatine+proton
Catalysed by CKM or CKMT2 or CKB or CKMT1A
Reaction pageReversibleBalancedEC 2.7.3.2cytosol
Human-GEM MAR04584CC BY 4.0Reference data
5 names
Resolves to: CKM
Reaction pageReversibleBalancedEC 2.7.3.2mitochondrial matrix
Human-GEM MAR08427CC BY 4.0Reference data
creatine+ATP(4-)N-phosphocreatine+ADP(3-)+hydron
Catalysed by CKM or CKB or CKMT1A or CKMT2
Reaction pageLeft to rightBalanced
Rhea RHEA:17157CC BY 4.0Reference data