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Proteins/UNIPROT:P12532
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Function from UniProtKB (P12532), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
71 statements
71 statements · 5 reference databases · Subject: CKMT1A · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
ATP+creatineADP+N-phosphocreatine+proton
Catalysed by CKM or CKMT2 or CKB or CKMT1A
Reaction pageReversibleBalancedEC 2.7.3.2cytosol
Human-GEM MAR04584CC BY 4.0Reference data
6 names
Resolves to: CKMT1A
Reaction pageReversibleBalancedEC 2.7.3.2mitochondrial matrix
Human-GEM MAR08427CC BY 4.0Reference data
creatine+ATP(4-)N-phosphocreatine+ADP(3-)+hydron
Catalysed by CKM or CKB or CKMT1A or CKMT2
Reaction pageLeft to rightBalanced
Rhea RHEA:17157CC BY 4.0Reference data