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Proteins/UNIPROT:Q9BYV7
Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules..
Function from UniProtKB (Q9BYV7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
53 statements
53 statements · 9 reference databases · Subject: BCO2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
12 reactions
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2 or BCO2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.14.19cytosol
Human-GEM MAR01999CC BY 4.0Reference data
4 names
Resolves to: BCO2
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:26389CC BY 4.0Reference data
zeaxanthin+2dioxygen4,9-dimethyldodeca-2,4,6,8,10-pentaenedial+2(3R)-hydroxy-beta-ionone
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:26393CC BY 4.0Reference data
zeaxanthin+dioxygen(3R)-3-hydroxy-10'-apo-beta-carotenal+(3R)-hydroxy-beta-ionone
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68104CC BY 4.0Reference data
(3R)-3-hydroxy-10'-apo-beta-carotenal+dioxygen4,9-dimethyldodeca-2,4,6,8,10-pentaenedial+(3R)-hydroxy-beta-ionone
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68424CC BY 4.0Reference data
lutein+dioxygen(3R,6R)-hydroxy-alpha-ionone+(3R)-3-hydroxy-10'-apo-beta-carotenal
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68428CC BY 4.0Reference data
lutein+dioxygen(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal+(3R)-hydroxy-beta-ionone
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68432CC BY 4.0Reference data
(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal+dioxygen(3R,6R)-hydroxy-alpha-ionone+4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68436CC BY 4.0Reference data
beta-cryptoxanthin+dioxygenall-trans-10'-apo-beta-carotenal+(3R)-hydroxy-beta-ionone
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68440CC BY 4.0Reference data
CHEBI:177905+dioxygenCHEBI:177906+CHEBI:67207
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68444CC BY 4.0Reference data
CHEBI:177907+dioxygenCHEBI:177908+CHEBI:67207
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68448CC BY 4.0Reference data
all-trans-10'-apo-beta-carotenal+dioxygenbeta-ionone+4,9-dimethyldodeca-2,4,6,8,10-pentaenedial
Catalysed by BCO2
Reaction pageLeft to rightBalanced
Rhea RHEA:68452CC BY 4.0Reference data