Proteins/UNIPROT:P20333

TNFRSF1B

ProteinUNIPROT:P203331 finding

Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity..

Function from UniProtKB (P20333), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

Findings that name it directly

astaxanthinbindsInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.

What the reference databases state

Statements

48 statements

48 statements · 4 reference databases · Subject: TNFRSF1B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CAV1 interacts with TNFRSF1BProteinHetionet hetionet:interacts:7133-857Inferred only
CD14 interacts with TNFRSF1BProteinHetionet hetionet:interacts:7133-929Inferred only
FANCD2 interacts with TNFRSF1BProteinHetionet hetionet:interacts:2177-7133Inferred only
KRT18 interacts with TNFRSF1BProteinHetionet hetionet:interacts:3875-7133Inferred only
LTA interacts with TNFRSF1BProteinHetionet hetionet:interacts:4049-7133Inferred only
TNFRSF1B interacts with TDP2ProteinHetionet hetionet:interacts:51567-7133Inferred only
TNF interacts with TNFRSF1BProteinHetionet hetionet:interacts:7124-7133Inferred only
TNFRSF1B interacts with TRAF1ProteinHetionet hetionet:interacts:7133-7185Inferred only
TNFRSF1B interacts with TRAF2ProteinHetionet hetionet:interacts:7133-7186Inferred only
TNFRSF1B interacts with TRAF3ProteinHetionet hetionet:interacts:7133-7187Inferred only
TNFRSF1B interacts with TRAF6ProteinHetionet hetionet:interacts:7133-7189Inferred only
TNFRSF1B interacts with TRAIPProteinHetionet hetionet:interacts:10293-7133Inferred only

Show the remaining 36

TRIM37 interacts with TNFRSF1BProteinHetionet hetionet:interacts:4591-7133Inferred only
TNFRSF1B interacts with UBQLN1ProteinHetionet hetionet:interacts:29979-7133Inferred only
TNFRSF1B interacts with ZNF420ProteinHetionet hetionet:interacts:147923-7133Inferred only
TNFRSF1B participates in ApoptosisPathwayWikiPathways WP254Inferred only
TNFRSF1B participates in Apoptosis modulation and signalingPathwayWikiPathways WP1772Inferred only
TNFRSF1B participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
TNFRSF1B participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
TNFRSF1B participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TNFRSF1B participates in Inflammatory response pathwayPathwayWikiPathways WP453Inferred only
TNFRSF1B participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
TNFRSF1B participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
TNFRSF1B participates in Interleukin-10 signalingPathwayReactome R-HSA-6783783Inferred only
TNFRSF1B participates in Interleukin-4 and Interleukin-13 signalingPathwayReactome R-HSA-6785807Inferred only
TNFRSF1B participates in Neuroinflammation and glutamatergic signalingPathwayWikiPathways WP5083Inferred only
TNFRSF1B participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
TNFRSF1B participates in Oxidative damage responsePathwayWikiPathways WP3941Inferred only
TNFRSF1B participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
TNFRSF1B participates in TNF alpha signalingPathwayWikiPathways WP231Inferred only
TNFRSF1B participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
TNFRSF1B participates in TNFs bind their physiological receptorsPathwayReactome R-HSA-5669034Inferred only
TNFRSF1B participates in TYROBP causal network in microgliaPathwayWikiPathways WP3945Inferred only
TNFRSF1B regulates negative regulation of cardiac muscle hypertrophyBiological processgene ontology P20333|GO:0010614Inferred only
TNFRSF1B regulates negative regulation of extracellular matrix constituent secretionBiological processgene ontology P20333|GO:0003332Inferred only
TNFRSF1B regulates negative regulation of neuroinflammatory responseBiological processgene ontology P20333|GO:0150079Inferred only
TNFRSF1B regulates positive regulation of apoptotic process involved in morphogenesisBiological processgene ontology P20333|GO:1902339Inferred only
TNFRSF1B regulates positive regulation of membrane protein ectodomain proteolysisBiological processgene ontology P20333|GO:0051044Inferred only
TNFRSF1B regulates positive regulation of myelinationBiological processgene ontology P20333|GO:0031643Inferred only
TNFRSF1B regulates positive regulation of oligodendrocyte differentiationBiological processgene ontology P20333|GO:0048714Inferred only
TNFRSF1B regulates regulation of cytokine production involved in immune responseBiological processgene ontology P20333|GO:0002718Inferred only
TNFRSF1B regulates regulation of myelinationBiological processgene ontology P20333|GO:0031641Inferred only
TNFRSF1B regulates regulation of neuroinflammatory responseBiological processgene ontology P20333|GO:0150077Inferred only
TNFRSF1B regulates regulation of T cell cytokine productionBiological processgene ontology P20333|GO:0002724Inferred only
TNFRSF1B regulates regulation of T cell proliferationBiological processgene ontology P20333|GO:0042129Inferred only
BPHL increases the expression of TNFRSF1BProteinHetionet hetionet:regulates:670-7133Inferred only
PLPP3 increases the expression of TNFRSF1BProteinHetionet hetionet:regulates:8613-7133Inferred only
RNPS1 increases the expression of TNFRSF1BProteinHetionet hetionet:regulates:10921-7133Inferred only

Sources cited

1 paper

Subject: TNFRSF1B
Findings: 1
Papers: 1

Astaxanthin prevents postovulatory oocyte aging by targeting TNFR2 and inhibiting the TNF signaling pathway.record2025PMID:405983791 finding

Other names

14 names

Resolves to: TNFRSF1B

Also called: ]CD antigen CD120bEtanerceptp75p80 TNF-alpha receptorTBP-2TBPIITNF-R2TNF-RIITNFBRTNFR-IITNFR2Tumor necrosis factor receptor 2Tumor necrosis factor receptor type II

← Every protein Find it in the graph →