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Proteins/UNIPROT:O00299
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle..
Function from UniProtKB (O00299), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
156 statements
156 statements · 5 reference databases · Subject: CLIC1 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea, WikiPathways
7 reactions
L-dehydroascorbate+2glutathioneglutathione disulfide+L-ascorbic acid
Catalysed by CLIC1 or GSTO1 or GSTO2
Reaction pageLeft to rightBalanced
Rhea RHEA:24424CC BY 4.0Reference data
8 names
Resolves to: CLIC1
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLDN17 or SLC1A5 or SLC26A7 or CLIC4
Reaction pageDirection not assertedBalanced
Rhea RHEA:75347CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLCN1 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 or AQP6 or SLC5A8 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:75383CC BY 4.0Reference data