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Proteins/UNIPROT:P82251
Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules..
Function from UniProtKB (P82251), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 9 · transported by
9 compounds
9 compounds.
0 reported routes9 assembled routes
2 rows
257 statements
257 statements · 7 reference databases · Subject: SLC7A9 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
94 reactions
CHEBI:16856+hydrogencarbonate+taurochenodeoxycholateCHEBI:16856+hydrogencarbonate+taurochenodeoxycholate
Transported by SLC7A9 or SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01879CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+taurochenodeoxycholate
5 names
Resolves to: SLC7A9
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01892CC BY 4.0Reference data
hydrogencarbonate+2,4-dinitrophenyl-S-glutathione+taurochenodeoxycholatehydrogencarbonate+2,4-dinitrophenyl-S-glutathione+taurochenodeoxycholate
Transported by SLC7A9 or SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01893CC BY 4.0Reference data
L-citrulline+L-ornithineL-citrulline+L-ornithine
Transported by SLC7A9
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR02226CC BY 4.0Reference data
L-cysteine+L-leucineL-cysteine+L-leucine
Transported by SLC7A9 & SLC3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05550CC BY 4.0Reference data
glycine+CHEBI:18019glycine+CHEBI:18019
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05907CC BY 4.0Reference data
L-alanine+CHEBI:18019L-alanine+CHEBI:18019
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05908CC BY 4.0Reference data
L-glutamine+CHEBI:18019L-glutamine+CHEBI:18019
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05909CC BY 4.0Reference data
CHEBI:18019+L-seryl residueCHEBI:18019+L-seryl residue
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05910CC BY 4.0Reference data
CHEBI:18019+L-methionineCHEBI:18019+L-methionine
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05911CC BY 4.0Reference data
CHEBI:18019+L-tryptophanCHEBI:18019+L-tryptophan
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05912CC BY 4.0Reference data
CHEBI:18019+L-phenylalanineCHEBI:18019+L-phenylalanine
Transported by SLC7A9 & SLC3A1 & SLC7A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05913CC BY 4.0Reference data