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Proteins/UNIPROT:Q01650
Forms a heterodimer with SLC3A2 that functions as a sodium-independent transporter for large neutral amino acids. Functions as an obligatory amino acid antiporter, mediating the exchange of amino acids and amino acid-related compounds across the plasma membrane. Also mediates sodium-independent exchange of iodothyronines with neutral and aromatic L-alpha-amino acids. Mediates exchange of L-tryptophan with the tryptophan metabolites L-kynurenine and 3-hydroxy-L-kynurenine. Mediates cellular uptake of iodothyronines, including thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and 3,3'-diiodo-L-thyronine (3,3'-T2), and iodotyrosines including 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT). Involved in the uptake of methylmercury (MeHg) when administered as L-cysteine or D,L-homocysteine complexes, thereby contributing to metal ion homeostasis and toxicity. Involved in the cellular activity of low-molecular-weight nitrosothiols through stereoselective transport of L-nitrosocysteine (L-CNSO) across the plasma membrane. When associated with LAPTM4B, the heterodimer is recruited to lysosomes, where it promotes leucine uptake into these organelles and thereby contributes to mTORC1 activation..
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis..
Function from UniProtKB (Q01650), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 10 · transported by
10 compounds
10 compounds.
0 reported routes10 assembled routes
1 row
806 statements
806 statements · 7 reference databases · Subject: SLC7A5 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
225 reactions
Transported by SLC3A2 & SLC7A8 or SLC7A2 or SLC7A5 or SLC36A1 or SLC7A7 or SLC7A3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05070CC BY 4.0Reference data
13 names
Resolves to: SLC7A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05073CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05074CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC6A18
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05076CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05077CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05078CC BY 4.0Reference data
L-seryl residueL-seryl residue
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05079CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05080CC BY 4.0Reference data
L-phenylalanineL-phenylalanine
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05082CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05084CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05085CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05088CC BY 4.0Reference data