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Proteins/UNIPROT:Q8IVJ1
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity)..
Function from UniProtKB (Q8IVJ1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
22 statements
22 statements · 5 reference databases · Subject: SLC41A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
2 reactions
Transported by SLC41A1 or SLC41A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09586CC BY 4.0Reference data
magnesium(2+)+2sodium(1+)magnesium(2+)+2sodium(1+)
Transported by SLC41A1 or SLC41A3
Reaction pageLeft to rightBalanced
1 name
Resolves to: SLC41A1