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Proteins/UNIPROT:Q96S66
Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity)..
Function from UniProtKB (Q96S66), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
53 statements
53 statements · 5 reference databases · Subject: CLCC1 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea, WikiPathways
4 reactions
5 names
Resolves to: CLCC1
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLCN1 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 or AQP6 or SLC5A8 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:75383CC BY 4.0Reference data