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Proteins/UNIPROT:P17752

TPH1

Protein·UNIPROT:P17752Tryptophan 5-hydroxylase 11 compound

Open in the graph

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis..

Function from UniProtKB (P17752), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

5-hydroxy-L-tryptophanCompoundCHEBI:17780Inferred only20 paths20 endpoints

What the reference databases state

Statements

33 statements

33 statements · 7 reference databases · Subject: TPH1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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TPH1 covaries with PEF1ProteinHetionet hetionet:covaries:553115-7166Inferred only
APP interacts with TPH1ProteinHetionet hetionet:interacts:351-7166Inferred only
PRKACA interacts with TPH1ProteinHetionet hetionet:interacts:5566-7166Inferred only
TPH1 interacts with YWHAHProteinHetionet hetionet:interacts:7166-7533Inferred only
TPH1 interacts with YWHAZProteinHetionet hetionet:interacts:7166-7534Inferred only
TPH1 participates in Amino acid metabolismPathwayWikiPathways WP3925Inferred only
TPH1 participates in Biogenic amine synthesisPathwayWikiPathways WP550Inferred only
TPH1 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
TPH1 participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
TPH1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
TPH1 participates in Metabolism of amine-derived hormonesPathwayReactome R-HSA-209776Inferred only
TPH1 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only

Show the remaining 21

TPH1 participates in Neurotransmitter disordersPathwayWikiPathways WP4220Inferred only
TPH1 participates in NGF-stimulated transcriptionPathwayReactome R-HSA-9031628Inferred only
TPH1 participates in Nuclear Events (kinase and transcription factor activation)PathwayReactome R-HSA-198725Inferred only
TPH1 participates in Serotonin and melatonin biosynthesisPathwayReactome R-HSA-209931Inferred only
TPH1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TPH1 participates in Signaling by NTRK1 (TRKA)PathwayReactome R-HSA-187037Inferred only
TPH1 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
TPH1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
TPH1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
TPH1 participates in Tryptophan metabolismPathwayWikiPathways WP465Inferred only
TPH1 participates in Vitamin D sensitive calcium signaling in depressionPathwayWikiPathways WP4698Inferred only
TPH1 regulates regulation of hemostasisBiological processgene ontology P17752|GO:1900046Inferred only
TPH1 requires the cofactor iron(2+)CompoundUniProt P17752Inferred only
(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin is a substrate of TPH1CompoundRhea RHEA:16709Inferred only
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin is a substrate of TPH1CompoundRhea RHEA:16709Inferred only
5-hydroxy-L-tryptophan is a substrate of TPH1CompoundRhea RHEA:16709Inferred only
5,6,7,8-tetrahydrobiopterin is a substrate of TPH1CompoundHuman-GEM MAR04537Inferred only
5,6,7,8-tetrahydrobiopterin is a substrate of TPH1CompoundHuman-GEM MAR02119Inferred only
L-tryptophan is a substrate of TPH1CompoundHuman-GEM MAR02119Inferred only
L-tryptophan is a substrate of TPH1CompoundRhea RHEA:16709Inferred only
L-tryptophan is a substrate of TPH1CompoundHuman-GEM MAR04537Inferred only

Reactions

3 reactions

dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan5-hydroxytryptophan+MAM01698c+water
Catalysed by TPH1 or TPH2
Reaction pageLeft to rightBalancedEC 1.14.16.4cytosol
Human-GEM MAR02119CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan4a-hydroxytetrahydrobiopterin+

Other names

4 names

Resolves to: TPH1

Also called: TPHTPRHTRPHTryptophan 5-monooxygenase 1

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5-hydroxytryptophan

Catalysed by TPH1 or TPH2

Reaction pageLeft to rightBalancedEC 1.14.16.4cytosol

Human-GEM MAR04537CC BY 4.0Reference data

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin+L-tryptophan+dioxygen5-hydroxy-L-tryptophan+(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by TPH1 or TPH2

Reaction pageDirection not assertedBalanced

Rhea RHEA:16709CC BY 4.0Reference data