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Proteins/UNIPROT:P29474
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets..
[Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Function from UniProtKB (P29474), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
402 statements
402 statements · 9 reference databases · Subject: NOS3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
L-arginine+2NADPH(4-)+2dioxygenL-citrulline+2water+2NADP(3-)+nitric oxide
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageLeft to rightUnbalancedEC 1.14.13.39cytosol
Human-GEM MAR02023CC BY 4.0Reference data
8 names
Resolves to: NOS3
Reaction pageLeft to rightBalancedEC 1.14.13.39cytosol
Human-GEM MAR03993CC BY 4.0Reference data
L-arginine+proton+NADPH(4-)+dioxygenwater+N(5)-[(Z)-amino(hydroxyimino)methyl]ornithine+NADP(3-)
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageReversibleBalancedEC 1.14.13.39cytosol
Human-GEM MAR04190CC BY 4.0Reference data
2L-arginine+3NADPH(4-)+4dioxygen+hydron2L-citrulline+2nitric oxide+3NADP(3-)+4water
Catalysed by NOS3 or NOS1 or NOS2
Reaction pageLeft to rightBalanced
Rhea RHEA:19897CC BY 4.0Reference data