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Proteins/UNIPROT:Q16518
Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity)..
Function from UniProtKB (Q16518), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
8 rows
20 statements
20 statements · 7 reference databases · Subject: RPE65 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
water+an all-trans-retinyl ester11-cis-retinol+proton+fatty acid
Catalysed by RPE65
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.64cytosol
Human-GEM MAR06637CC BY 4.0Reference data
Catalysed by RPE65
Reaction pageDirection not assertedBalanced
Rhea RHEA:12729CC BY 4.0Reference data
5 names
Resolves to: RPE65
Catalysed by RPE65
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:31771CC BY 4.0Reference data
all-trans-retinyl hexadecanoate+water11-cis-retinol+hexadecanoate+hydron
Catalysed by RPE65
Reaction pageDirection not assertedBalanced
Rhea RHEA:31775CC BY 4.0Reference data