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Proteins/UNIPROT:P00480
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion..
Function from UniProtKB (P00480), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
32 statements
32 statements · 7 reference databases · Subject: OTC · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
L-citrulline+proton+phosphate(3-)carbamoyl phosphate+L-ornithine
Catalysed by OTC
Reaction pageReversibleBalancedEC 2.1.3.3mitochondrial matrix
Human-GEM MAR03809CC BY 4.0Reference data
carbamoyl phosphate+L-ornithineL-citrulline+hydrogenphosphate+hydron
Catalysed by OTC
2 names
Resolves to: OTC
Rhea RHEA:19513CC BY 4.0Reference data