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Proteins/UNIPROT:Q9Y696
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3..
Function from UniProtKB (Q9Y696), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
285 statements
285 statements · 5 reference databases · Subject: CLIC4 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Rhea
7 reactions
2 names
Resolves to: CLIC4
Transported by SLC35F4 or SLC22A2 or SLC22A1 or SLC22A3 or SLC35G4 or CHRNA7 or CLDN2 or SLC25A48 or SLC35F2 or SLC35F3 or SLC35F5 or FLVCR2 and 2 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:32751CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLDN17 or SLC1A5 or SLC26A7 or CLIC4
Reaction pageDirection not assertedBalanced
Rhea RHEA:75347CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLCN1 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 or AQP6 or SLC5A8 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:75383CC BY 4.0Reference data