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Proteins/UNIPROT:Q8IWU9
Neuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep (By similarity)..
Function from UniProtKB (Q8IWU9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
23 statements
23 statements · 7 reference databases · Subject: TPH2 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan5-hydroxytryptophan+MAM01698c+water
Reaction pageLeft to rightBalancedEC 1.14.16.4cytosol
Human-GEM MAR02119CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan4a-hydroxytetrahydrobiopterin+
3 names
Resolves to: TPH2
Reaction pageLeft to rightBalancedEC 1.14.16.4cytosol
Human-GEM MAR04537CC BY 4.0Reference data
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin+L-tryptophan+dioxygen5-hydroxy-L-tryptophan+(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
Reaction pageDirection not assertedBalanced
Rhea RHEA:16709CC BY 4.0Reference data