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Proteins/UNIPROT:P15309
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma..
[Isoform 2]: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity)..
[PAPf39]: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Assembly of SEVI amyloid fibrils and their amplification of HIV infection is inhibited by WW61, a non-natural hexapeptide inhibitor (Trp-His-Lys-chAla-Trp-hydroxyTic). The target cell attachment and enhancement of HIV infection is also inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection..
Function from UniProtKB (P15309), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
19 statements
19 statements · 7 reference databases · Subject: ACP3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
24 reactions
water+MAM03200ladenosine+phosphate(3-)
Catalysed by ACP3 or ACP5 or ACP2
Reaction pageLeft to rightBalancedEC 3.1.3.2lysosome
Human-GEM MAR00046CC BY 4.0Reference data
11 names
Resolves to: ACP3
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04010CC BY 4.0Reference data
dTMP+waterphosphate(3-)+thymidine
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B or NT5M
Reaction pageLeft to rightBalancedEC 3.1.3.5, 3.1.3.35cytosol
Human-GEM MAR04056CC BY 4.0Reference data
AMP+wateradenosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B or NT5M
Reaction pageLeft to rightBalancedEC 3.1.3.5extracellular space
Human-GEM MAR04081CC BY 4.0Reference data
AMP+wateradenosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5mitochondrial matrix
Human-GEM MAR04082CC BY 4.0Reference data
cytidine 5'-monophosphate+watercytidine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5E or NT5C3B or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04177CC BY 4.0Reference data
cytidine 5'-monophosphate+watercytidine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5extracellular space
Human-GEM MAR04179CC BY 4.0Reference data
water+nicotinic acid D-ribonucleotidebeta-D-ribosylnicotinate+phosphate(3-)
Catalysed by ACP3 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04252CC BY 4.0Reference data
water+NMN zwitterionbeta-nicotinamide D-riboside+phosphate(3-)
Catalysed by ACP3 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04264CC BY 4.0Reference data
water+NADP(3-)NAD(+)+phosphate(3-)
Catalysed by ACP3 or ACP5 or ACP4 or PXYLP1 or ACP7
Reaction pageLeft to rightBalancedEC 3.1.3.2cytosol
Human-GEM MAR04270CC BY 4.0Reference data
water+CHEBI:17202inosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C or NT5E or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04417CC BY 4.0Reference data
GMP+waterguanosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04449CC BY 4.0Reference data