Loading the page.
Proteins/UNIPROT:Q969G6
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase..
Function from UniProtKB (Q969G6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
136 statements
136 statements · 8 reference databases · Subject: RFK · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
ATP+riboflavinADP+CHEBI:17621+proton
Catalysed by RFK
Reaction pageLeft to rightBalancedEC 2.7.1.26cytosol
Human-GEM MAR06506CC BY 4.0Reference data
riboflavin+ATP(4-)FMN+ADP(3-)+hydron
Catalysed by RFK
2 names
Resolves to: RFK
Rhea RHEA:14357CC BY 4.0Reference data