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Proteins/UNIPROT:P14902
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection..
Function from UniProtKB (P14902), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
36 statements
36 statements · 8 reference databases · Subject: IDO1 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
dioxygen+L-tryptophanCHEBI:30249
Catalysed by IDO1 or TDO2 or IDO2
Reaction pageLeft to rightBalancedEC 1.13.11.11, 1.13.11.52cytosol
Human-GEM MAR04214CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
4 names
Resolves to: IDO1
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR04557CC BY 4.0Reference data
5-hydroxytryptophan+dioxygenMAM01108c
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR06716CC BY 4.0Reference data
D-tryptophan+dioxygenCHEBI:60051
Catalysed by IDO1
Reaction pageDirection not assertedBalanced
Rhea RHEA:14189CC BY 4.0Reference data
L-tryptophan+dioxygenN-formyl-L-kynurenine
Catalysed by IDO1 or TDO2 or IDO2
Reaction pageDirection not assertedBalanced
Rhea RHEA:24536CC BY 4.0Reference data