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Proteins/UNIPROT:P07711
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1. Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity)..
(Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell. Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins..
[Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor. Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties..
Function from UniProtKB (P07711), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
639 statements
639 statements · 3 reference databases · Subject: CTSL · Sources: Hetionet, Reactome, WikiPathways · Rows fetched: 300
15 reactions
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971
5 names
Resolves to: CTSL
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05261CC BY 4.0Reference data
MAM01345l+417ATP+834water417ADP+26L-alanine+7L-arginine+19L-asparagine+24L-aspartate+3L-cysteine+32L-glutamate(1-)+18L-glutamine+24glycine+432proton+13CHEBI:15971+20L-isoleucine+51L-leucine+34CHEBI:18019+10L-methionine+27L-phenylalanine+417phosphate(3-)+19CHEBI:17203+25L-seryl residue+30CHEBI:16857+3L-tryptophan+6CHEBI:17895+27L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05263CC BY 4.0Reference data
MAM01351l+4560ATP+9120water4560ADP+275L-alanine+150L-arginine+247L-asparagine+233L-aspartate+25L-cysteine+298L-glutamate(1-)+230L-glutamine+207glycine+4584proton+115CHEBI:15971+285L-isoleucine+533L-leucine+357CHEBI:18019+79L-methionine+224L-phenylalanine+4560phosphate(3-)+171CHEBI:17203+392L-seryl residue+300CHEBI:16857+37L-tryptophan+151CHEBI:17895+252L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05265CC BY 4.0Reference data
2673ATP+MAM01827l+5346water2673ADP+134L-alanine+134L-arginine+138L-asparagine+176L-aspartate+48L-cysteine+186L-glutamate(1-)+110L-glutamine+262glycine+2747proton+62CHEBI:15971+104L-isoleucine+166L-leucine+154CHEBI:18019+48L-methionine+98L-phenylalanine+2673phosphate(3-)+114CHEBI:17203+278L-seryl residue+182CHEBI:16857+60L-tryptophan+98CHEBI:17895+122L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05272CC BY 4.0Reference data
405ATP+810water+MAM02044l405ADP+30L-alanine+9L-arginine+21L-asparagine+25L-aspartate+12L-cysteine+25L-glutamate(1-)+17L-glutamine+31glycine+411proton+13CHEBI:15971+18L-isoleucine+31L-leucine+35CHEBI:18019+5L-methionine+8L-phenylalanine+405phosphate(3-)+21CHEBI:17203+18L-seryl residue+22CHEBI:16857+8L-tryptophan+21CHEBI:17895+36L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05274CC BY 4.0Reference data
809ATP+1618water+MAM02753l809ADP+37L-alanine+42L-arginine+40L-asparagine+36L-aspartate+48L-cysteine+56L-glutamate(1-)+31L-glutamine+62glycine+810proton+24CHEBI:15971+22L-isoleucine+48L-leucine+49CHEBI:18019+11L-methionine+21L-phenylalanine+809phosphate(3-)+69CHEBI:17203+56L-seryl residue+61CHEBI:16857+19L-tryptophan+30CHEBI:17895+48L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05276CC BY 4.0Reference data
621ATP+1242water+MAM02802l621ADP+42L-alanine+44L-arginine+25L-asparagine+35L-aspartate+26L-cysteine+51L-glutamate(1-)+26L-glutamine+49glycine+634proton+13CHEBI:15971+22L-isoleucine+51L-leucine+29CHEBI:18019+9L-methionine+21L-phenylalanine+621phosphate(3-)+33CHEBI:17203+38L-seryl residue+36CHEBI:16857+14L-tryptophan+21CHEBI:17895+37L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05278CC BY 4.0Reference data
MAM00186l+697ATP+1394water697ADP+61L-alanine+27L-arginine+34L-asparagine+45L-aspartate+40L-cysteine+42L-glutamate(1-)+17L-glutamine+52glycine+699proton+19CHEBI:15971+15L-isoleucine+65L-leucine+58CHEBI:18019+10L-methionine+28L-phenylalanine+697phosphate(3-)+32CHEBI:17203+41L-seryl residue+30CHEBI:16857+8L-tryptophan+26CHEBI:17895+48L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05280CC BY 4.0Reference data
MAM01359l+316ATP+632water316ADP+39L-alanine+34L-arginine+L-asparagine+11L-aspartate+2L-cysteine+40L-glutamate(1-)+32L-glutamine+18glycine+320proton+2CHEBI:15971+2L-isoleucine+41L-leucine+13CHEBI:18019+8L-methionine+4L-phenylalanine+316phosphate(3-)+8CHEBI:17203+14L-seryl residue+12CHEBI:16857+8L-tryptophan+4CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05282CC BY 4.0Reference data
MAM01350l+266ATP+532water266ADP+23L-alanine+17L-arginine+5L-asparagine+16L-aspartate+30L-glutamate(1-)+19L-glutamine+11glycine+273proton+6CHEBI:15971+41L-leucine+22CHEBI:18019+4L-methionine+8L-phenylalanine+266phosphate(3-)+10CHEBI:17203+16L-seryl residue+12CHEBI:16857+5L-tryptophan+7CHEBI:17895+15L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05284CC BY 4.0Reference data
284ATP+568water+MAM02935l284ADP+21L-alanine+20L-arginine+11L-asparagine+10L-aspartate+5L-cysteine+22L-glutamate(1-)+17L-glutamine+21glycine+277proton+6CHEBI:15971+10L-isoleucine+31L-leucine+19CHEBI:18019+12L-methionine+6L-phenylalanine+284phosphate(3-)+12CHEBI:17203+20L-seryl residue+12CHEBI:16857+5L-tryptophan+4CHEBI:17895+21L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05285CC BY 4.0Reference data