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Proteins/UNIPROT:Q9NQZ5
Mediates non-vesicular transfer of phosphatidylcholine to mitochondria, thereby maintaining mitochondrial membrane lipid composition, cristae organization, and respiratory function across diverse tissues..
[StAR-related lipid transfer protein 7, mitochondrial]: Transfers phosphatidylcholine (PC) from the endoplasmic reticulum to the mitochondrial outer membrane at ER-mitochondria contact sites, thereby maintaining mitochondrial PC content, respiratory complex stability and mitochondrial cristae morphology..
[StAR-related lipid transfer protein 7, mature]: Transfers phosphatidylcholine (PC) between the mitochondrial outer and inner membranes, contributing to mitochondrial lipid homeostasis. The mature cytosolic and intermembrane space forms of STARD7 mediate non-vesicular PC transport by transiently associating with mitochondrial membranes. Required for normal cristae architecture and optimal activity of the respiratory chain. Mediates intracellular distribution of coenzyme Q (ubiquinone), the intermembrane space form supports mitochondrial coenzyme Q biosynthesis and the cytosolic form transfers coenzyme Q to extramitochondrial membranes, enhancing antioxidant protection and limiting ferroptosis sensitivity..
Function from UniProtKB (Q9NQZ5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
231 statements
231 statements · 8 reference databases · Subject: STARD7 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
CHEBI:1307929+MAM02935cMAM01511c
Catalysed by STARD7 or STARD8 or STARD13 or STAR or STARD9 or STARD4 or STARD5 or STARD6 or STARD10
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR01924CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
8 names
Resolves to: STARD7
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
Transported by STARD7
Reaction pageDirection not assertedBalanced
Rhea RHEA:86447CC BY 4.0Reference data