Loading the page.
Proteins/UNIPROT:P07339
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease..
Function from UniProtKB (P07339), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
207 statements
207 statements · 4 reference databases · Subject: CTSD · Sources: gene ontology, Hetionet, Reactome, WikiPathways
15 reactions
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971
2 names
Resolves to: CTSD
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05261CC BY 4.0Reference data
MAM01345l+417ATP+834water417ADP+26L-alanine+7L-arginine+19L-asparagine+24L-aspartate+3L-cysteine+32L-glutamate(1-)+18L-glutamine+24glycine+432proton+13CHEBI:15971+20L-isoleucine+51L-leucine+34CHEBI:18019+10L-methionine+27L-phenylalanine+417phosphate(3-)+19CHEBI:17203+25L-seryl residue+30CHEBI:16857+3L-tryptophan+6CHEBI:17895+27L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05263CC BY 4.0Reference data
MAM01351l+4560ATP+9120water4560ADP+275L-alanine+150L-arginine+247L-asparagine+233L-aspartate+25L-cysteine+298L-glutamate(1-)+230L-glutamine+207glycine+4584proton+115CHEBI:15971+285L-isoleucine+533L-leucine+357CHEBI:18019+79L-methionine+224L-phenylalanine+4560phosphate(3-)+171CHEBI:17203+392L-seryl residue+300CHEBI:16857+37L-tryptophan+151CHEBI:17895+252L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05265CC BY 4.0Reference data
2673ATP+MAM01827l+5346water2673ADP+134L-alanine+134L-arginine+138L-asparagine+176L-aspartate+48L-cysteine+186L-glutamate(1-)+110L-glutamine+262glycine+2747proton+62CHEBI:15971+104L-isoleucine+166L-leucine+154CHEBI:18019+48L-methionine+98L-phenylalanine+2673phosphate(3-)+114CHEBI:17203+278L-seryl residue+182CHEBI:16857+60L-tryptophan+98CHEBI:17895+122L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05272CC BY 4.0Reference data
405ATP+810water+MAM02044l405ADP+30L-alanine+9L-arginine+21L-asparagine+25L-aspartate+12L-cysteine+25L-glutamate(1-)+17L-glutamine+31glycine+411proton+13CHEBI:15971+18L-isoleucine+31L-leucine+35CHEBI:18019+5L-methionine+8L-phenylalanine+405phosphate(3-)+21CHEBI:17203+18L-seryl residue+22CHEBI:16857+8L-tryptophan+21CHEBI:17895+36L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05274CC BY 4.0Reference data
809ATP+1618water+MAM02753l809ADP+37L-alanine+42L-arginine+40L-asparagine+36L-aspartate+48L-cysteine+56L-glutamate(1-)+31L-glutamine+62glycine+810proton+24CHEBI:15971+22L-isoleucine+48L-leucine+49CHEBI:18019+11L-methionine+21L-phenylalanine+809phosphate(3-)+69CHEBI:17203+56L-seryl residue+61CHEBI:16857+19L-tryptophan+30CHEBI:17895+48L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05276CC BY 4.0Reference data
621ATP+1242water+MAM02802l621ADP+42L-alanine+44L-arginine+25L-asparagine+35L-aspartate+26L-cysteine+51L-glutamate(1-)+26L-glutamine+49glycine+634proton+13CHEBI:15971+22L-isoleucine+51L-leucine+29CHEBI:18019+9L-methionine+21L-phenylalanine+621phosphate(3-)+33CHEBI:17203+38L-seryl residue+36CHEBI:16857+14L-tryptophan+21CHEBI:17895+37L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05278CC BY 4.0Reference data
MAM00186l+697ATP+1394water697ADP+61L-alanine+27L-arginine+34L-asparagine+45L-aspartate+40L-cysteine+42L-glutamate(1-)+17L-glutamine+52glycine+699proton+19CHEBI:15971+15L-isoleucine+65L-leucine+58CHEBI:18019+10L-methionine+28L-phenylalanine+697phosphate(3-)+32CHEBI:17203+41L-seryl residue+30CHEBI:16857+8L-tryptophan+26CHEBI:17895+48L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05280CC BY 4.0Reference data
MAM01359l+316ATP+632water316ADP+39L-alanine+34L-arginine+L-asparagine+11L-aspartate+2L-cysteine+40L-glutamate(1-)+32L-glutamine+18glycine+320proton+2CHEBI:15971+2L-isoleucine+41L-leucine+13CHEBI:18019+8L-methionine+4L-phenylalanine+316phosphate(3-)+8CHEBI:17203+14L-seryl residue+12CHEBI:16857+8L-tryptophan+4CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05282CC BY 4.0Reference data
MAM01350l+266ATP+532water266ADP+23L-alanine+17L-arginine+5L-asparagine+16L-aspartate+30L-glutamate(1-)+19L-glutamine+11glycine+273proton+6CHEBI:15971+41L-leucine+22CHEBI:18019+4L-methionine+8L-phenylalanine+266phosphate(3-)+10CHEBI:17203+16L-seryl residue+12CHEBI:16857+5L-tryptophan+7CHEBI:17895+15L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05284CC BY 4.0Reference data
284ATP+568water+MAM02935l284ADP+21L-alanine+20L-arginine+11L-asparagine+10L-aspartate+5L-cysteine+22L-glutamate(1-)+17L-glutamine+21glycine+277proton+6CHEBI:15971+10L-isoleucine+31L-leucine+19CHEBI:18019+12L-methionine+6L-phenylalanine+284phosphate(3-)+12CHEBI:17203+20L-seryl residue+12CHEBI:16857+5L-tryptophan+4CHEBI:17895+21L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05285CC BY 4.0Reference data