CHEBI:16857

Three steps

• a 3-acylpyruvateReach from here →
  1. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SDS, SDSL, AGXT2, FAHD1cytosol

• succinyl-CoAReach from here →
  1. Acetylation of Threonine
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
  3. (R)-methylmalonyl-CoA = succinyl-CoA

  Catalysed by ALDH6A1, MMUTmitochondrial matrixOne of 3 routes

• (2E)-butenoyl-CoAReach from here →
  1. Acetylation of Threonine
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 4 moremitochondrial matrix, cytosolOne of 4 routes

• 3-methyl-(2E)-glutaconyl-CoAReach from here →
  1. Acetylation of Threonine
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)
  3. 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by GLYAT, MCCC1, MCCC2mitochondrial matrixOne of 2 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. Acetylation of Threonine
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 moremitochondrial matrix, cytosol

• (2E)-glutaconyl-CoAReach from here →
  1. Acetylation of Threonine
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2

  Catalysed by CPT1A, CPT1C, CPT1B, ACOX1mitochondrial matrix, cytosol

• acryloyl-CoAReach from here →
  1. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  2. 2-oxobutyrate oxidation
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by SDS, SDSL, ACADS, ACADSBcytosol, mitochondrial matrix

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. Acetylation of Threonine
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
  3. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 moremitochondrial matrix, cytosol

• benzoyl-CoAReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. Hippurate (Benzoylglycinate) Formation
  3. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)

  Catalysed by GLYATcytosol, mitochondrial matrix

• hexadecanoyl-CoAReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by GLYATL3cytosolOne of 3 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. Acetylation of Threonine
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 moremitochondrial matrix, cytosol

• propanoyl-CoAReach from here →
  1. Acetylation of Threonine
  2. (S)-methylmalonyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

  Catalysed by ECHDC1mitochondrial matrix

• prostaglandin E1Reach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin D2Reach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GSS, GPX5, GPX1, GPX2 and 6 morecytosolOne of 3 routes

• S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
  1. Acetylation of Threonine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by SAT1, SAT2, SRMmitochondrial matrix, cytosol

• 7,8-dihydrofolateReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by SHMT1, DHFR, DHFR2cytosolOne of 5 routes

• 5-formimidoyltetrahydrofolateReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by SHMT1, FTCDcytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 3 routes

• (R)-S-lactoylglutathioneReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GSS, GLO1, GLOD4cytosolOne of 3 routes

• propane-1,3-diamineReach from here →
  1. Acetylation of Threonine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

  Catalysed by SAT1, SAT2, DHPSmitochondrial matrix, cytosol

• carnosineReach from here →
  1. transport of alanine and threonine (cytosol to extracellular)
  2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLC7A5, SLC7A10, CARNS1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-oxoadipateReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by AADATcytosol

• 3,5-diiodo-L-tyrosineReach from here →
  1. transport of threonine and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)
  3. thyroid peroxidase (3-iodo-L-tyrosine)

  Catalysed by SLC7A5, TPOextracellular space, cytosolOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by ALDH3A1, ALDH3B1, ALDH1A3, ALDH3B2 and 1 morecytosolOne of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Acetylation of Threonine
  2. Palmitate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moremitochondrial matrix, cytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. Acetylation of Threonine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 moremitochondrial matrix, Golgi apparatus

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. transport of alanine and threonine (cytosol to extracellular)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC7A5, AGXT2, ADSS2, ADSS1extracellular space, cytosolOne of 2 routes

• O-acetyl-(R)-carnitineReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. Carnitine Transport by Atb0
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by SLC6A14, CPT1A, CPT1C, CPT1Bextracellular space, cytosolOne of 9 routes

• ethanolamineReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate
  3. phosphoethanolamine + H2O = ethanolamine + phosphate

  Catalysed by ETNPPL, ALPL, PHOSPHO1cytosol

• beta-D-fructose 6-phosphateReach from here →
  1. transport of glutamine and threonine (cytosol to extracellular)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, GFPT2 and 3 moreextracellular space, cytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylation of Threonine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• S-formylglutathioneReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by GSS, ADH1C, ADH1A, ADH5 and 3 morecytosolOne of 2 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SDS, SDSL, AGXT2cytosol

• succinate semialdehydeReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

  Catalysed by SLC6A14, SLC6A12, ABATextracellular space, cytosol

• hypotaurineReach from here →
  1. transport of cysteine and threonine (cytosol to extracellular)
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2

  Catalysed by SLC7A5, CDO1, GADL1, CSADextracellular space, cytosol

• N-sulfo-D-glucosamineReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC6A14, SLC26A6, SGSHextracellular space, cytosol

• CDP-ethanolamineReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate
  3. phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate

  Catalysed by ETNPPL, PCYT2cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Acetylation of Threonine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 moremitochondrial matrix, Golgi apparatus

• dehydroepiandrosterone 3-sulfateReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SLC6A14, SLC26A6, STSextracellular space, cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. Acetylation of Threonine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moremitochondrial matrix, Golgi apparatus

• dimethylamineReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by AGXT2, DDAH1cytosolOne of 2 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. transport of alanine and threonine (cytosol to extracellular)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC7A5, AGXT2, AGAextracellular space, cytosol

• L-cysteateReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. L-cysteate + H(+) = taurine + CO2

  Catalysed by SLC6A14, SLC6A6, GADL1, CSADextracellular space, cytosol

• N(1)-acetylspermineReach from here →
  1. Acetylation of Threonine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

  Catalysed by SAT1, SAT2, PAOXmitochondrial matrix, cytosol

• porphobilinogenReach from here →
  1. L-threonine acetaldehyde-lyase (glycine-forming)
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
  3. 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing

  Catalysed by ALAS1, ALAS2, CPNE7, ALADcytosol, mitochondrial matrixOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SLC6A14, SLC26A6, PAPSS1, PAPSS2extracellular space, cytosolOne of 4 routes