Loading the page.
Proteins/UNIPROT:O94808
Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway. Via control of the HPB, likely regulates the availability of precursors for N- and O-linked protein glycosylation (By similarity). Exhibits feedback inhibition by UDP-N-acetylglucosamine (UDP-GlcNAc), although to a lesser extent than GFPT1..
Function from UniProtKB (O94808), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
66 statements
66 statements · 5 reference databases · Subject: GFPT2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
2 reactions
keto-D-fructose 6-phosphate+L-glutaminealpha-D-glucosamine 6-phosphate+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.16cytosol
Human-GEM MAR04300CC BY 4.0Reference data
D-fructose 6-phosphate+L-glutamineD-glucosamine 6-phosphate+L-glutamate(1-)
5 names
Resolves to: GFPT2
Reaction pageLeft to rightBalanced
Rhea RHEA:13237CC BY 4.0Reference data