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Proteins/UNIPROT:O43252
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells..
Function from UniProtKB (O43252), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
119 statements
119 statements · 6 reference databases · Subject: PAPSS1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
ATP+proton+sulfateadenosine 5'-phosphosulfate+diphosphate(3-)
Reaction pageLeft to rightBalancedEC 2.7.7.4cytosol
Human-GEM MAR04185CC BY 4.0Reference data
adenosine 5'-phosphosulfate+ATPADP+proton+3'-phospho-5'-adenylyl sulfate
Catalysed by
15 names
Resolves to: PAPSS1
Reaction pageLeft to rightBalancedEC 2.7.1.25cytosol
Human-GEM MAR04186CC BY 4.0Reference data
MAM01284c+ATPMAM00912c+ADP+proton
Reaction pageLeft to rightBalancedEC 2.7.1.25cytosol
Human-GEM MAR07129CC BY 4.0Reference data
sulfate+ATP(4-)+hydronadenosine 5'-phosphosulfate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:18133CC BY 4.0Reference data
adenosine 5'-phosphosulfate+ATP(4-)3'-phosphoadenylyl sulfate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:24152CC BY 4.0Reference data