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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P07202

TPO

Protein·UNIPROT:P07202Thyroid peroxidase1 compound

Open in the graph

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)..

Function from UniProtKB (P07202), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

iodideCompoundCHEBI:16382Inferred only56 paths14 endpoints

What the reference databases state

GenCC submitters' classifications

2 rows

familial thyroid dyshormonogenesis has a germline basis in TPODiseaseGenCC HGNC:12015|MONDO:0010132Inferred only
thyroid dyshormonogenesis 2A has a germline basis in TPODiseaseGenCC HGNC:12015|MONDO:0010133Inferred only

Statements

50 statements

50 statements · 8 reference databases · Subject: TPO · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

C6orf132 covaries with TPOProteinHetionet hetionet:covaries:647024-7173Inferred only
CCRL2 covaries with TPOProteinHetionet hetionet:covaries:7173-9034Inferred only
LCA5L covaries with TPOProteinHetionet hetionet:covaries:150082-7173Inferred only
MAMDC4 covaries with TPOProteinHetionet hetionet:covaries:158056-7173Inferred only
PTPRN2 covaries with TPOProteinHetionet hetionet:covaries:5799-7173Inferred only
TMEM132D covaries with TPOProteinHetionet hetionet:covaries:121256-7173Inferred only
TRAPPC12 covaries with TPOProteinHetionet hetionet:covaries:51112-7173Inferred only
TPO is expressed in left lobe of thyroid glandAnatomyBgee ENSG00000115705Inferred only
TPO is expressed in right lobe of thyroid glandAnatomyBgee ENSG00000115705Inferred only
TPO is expressed in thyroid glandAnatomyBgee ENSG00000115705Inferred only
TPO is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000115705Inferred only
TPO interacts with DUOX1ProteinHetionet hetionet:interacts:53905-7173Inferred only

Show the remaining 38

TPO interacts with TXNDC11ProteinHetionet hetionet:interacts:51061-7173Inferred only
TPO participates in Amino acid metabolismPathwayWikiPathways WP3925Inferred only
TPO participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
TPO participates in Development of pulmonary dendritic cells and macrophage subsetsPathwayWikiPathways WP3892Inferred only
TPO participates in Hematopoietic stem cell differentiationPathwayWikiPathways WP2849Inferred only
TPO participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
TPO participates in Metabolism of amine-derived hormonesPathwayReactome R-HSA-209776Inferred only
TPO participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
TPO participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
TPO participates in Pluripotent stem cell differentiation pathwayPathwayWikiPathways WP2848Inferred only
TPO participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
TPO participates in Thyroxine biosynthesisPathwayReactome R-HSA-209968Inferred only
TPO participates in Thyroxine thyroid hormone productionPathwayWikiPathways WP1981Inferred only
TPO requires the cofactor Ca(2+)CompoundUniProt P07202Inferred only
TPO requires the cofactor heme bCompoundUniProt P07202Inferred only
2-hydroxy-17beta-estradiol is a substrate of TPOCompoundHuman-GEM MAR02100Inferred only
2-hydroxy-17beta-estradiol is a substrate of TPOCompoundHuman-GEM MAR02099Inferred only
2-hydroxyestrone is a substrate of TPOCompoundHuman-GEM MAR02062Inferred only
2-hydroxyestrone is a substrate of TPOCompoundHuman-GEM MAR02061Inferred only
2-hydroxyestrone is a substrate of TPOCompoundHuman-GEM MAR02063Inferred only
3-iodo-L-tyrosine is a substrate of TPOCompoundHuman-GEM MAR06796Inferred only
3-iodo-L-tyrosine is a substrate of TPOCompoundHuman-GEM MAR06794Inferred only
3-iodo-L-tyrosine is a substrate of TPOCompoundHuman-GEM MAR08543Inferred only
3,5-diiodo-L-tyrosine is a substrate of TPOCompoundHuman-GEM MAR06795Inferred only
3,5-diiodo-L-tyrosine is a substrate of TPOCompoundHuman-GEM MAR06796Inferred only
4-hydroxy-17beta-estradiol is a substrate of TPOCompoundHuman-GEM MAR02088Inferred only
CHEBI:17895 is a substrate of TPOCompoundHuman-GEM MAR06793Inferred only
CHEBI:17895 is a substrate of TPOCompoundHuman-GEM MAR08544Inferred only
diiodine is a substrate of TPOCompoundHuman-GEM MAR08544Inferred only
diiodine is a substrate of TPOCompoundRhea RHEA:23336Inferred only
diiodine is a substrate of TPOCompoundHuman-GEM MAR06794Inferred only
diiodine is a substrate of TPOCompoundHuman-GEM MAR08543Inferred only
diiodine is a substrate of TPOCompoundHuman-GEM MAR06793Inferred only
dopamine quinone is a substrate of TPOCompoundHuman-GEM MAR06813Inferred only
iodide is a substrate of TPOCompoundRhea RHEA:48956Inferred only
iodide is a substrate of TPOCompoundHuman-GEM MAR06988Inferred only
iodide is a substrate of TPOCompoundRhea RHEA:23336Inferred only
iodide is a substrate of TPOCompoundRhea RHEA:48960Inferred only

Reactions

22 reactions

2-hydroxyestrone+proton+hydrogen peroxideMAM01792c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02061CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxide

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MAM01792l

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome

Human-GEM MAR02062CC BY 4.0Reference data

2-hydroxyestrone+proton+hydrogen peroxideMAM01792r+2water

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum

Human-GEM MAR02063CC BY 4.0Reference data

MAM01000c+proton+hydrogen peroxideMAM01794c+2water

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol

Human-GEM MAR02076CC BY 4.0Reference data

MAM01000r+proton+hydrogen peroxideMAM01794r+2water

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum

Human-GEM MAR02078CC BY 4.0Reference data

MAM00413c+2water4-hydroxy-17beta-estradiol+hydrogen peroxide

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol

Human-GEM MAR02088CC BY 4.0Reference data

MAM00411c+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol

Human-GEM MAR02099CC BY 4.0Reference data

MAM00411l+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide

Catalysed by MPO or TPO or PRDX6 or EPX or LPO

Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome

Human-GEM MAR02100CC BY 4.0Reference data

3hydrogen peroxide+2MAM03330c6proton+2water+2sulfite+2MAM03525c

Catalysed by TPO or PRDX6

Reaction pageLeft to rightBalancedEC 1.11.1.7cytosol

Human-GEM MAR02645CC BY 4.0Reference data

diiodine+CHEBI:178953-iodo-L-tyrosine+proton+iodide

Catalysed by TPO

Reaction pageLeft to rightBalancedEC 1.11.1.8cytosol

Human-GEM MAR06793CC BY 4.0Reference data

3-iodo-L-tyrosine+diiodine3,5-diiodo-L-tyrosine+proton+iodide

Catalysed by TPO

Reaction pageLeft to rightBalancedEC 1.11.1.8cytosol

Human-GEM MAR06794CC BY 4.0Reference data

23,5-diiodo-L-tyrosine+hydrogen peroxide2-aminoacrylic acid+2water+L-thyroxine

Catalysed by TPO

Reaction pageLeft to rightBalancedEC 1.11.1.8cytosol

Human-GEM MAR06795CC BY 4.0Reference data

Show the remaining 10