Compound
S-formylglutathione
The conjugate base of S-formylglutathione having anionic carboxy groups and a protonated primary amino group.
Definition from ChEBI (CHEBI:57688), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C11H16N3O7S
- Mass
- 334.33 g/mol
- Charge
- -1
- InChIKey
- FHXAGOICBFGEBF-BQBZGAKWSA-M
- SMILES
- [NH3+][C@@H](CCC(=O)N[C@@H](CSC=O)C(=O)NCC(=O)[O-])C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- ADH5ProteinUNIPROT:P11766metabolized byInferred only20 paths10 endpoints
- ADH1AProteinUNIPROT:P07327metabolized byInferred only17 paths17 endpoints
- ESDProteinUNIPROT:P10768substrate ofInferred only16 paths8 endpoints
- ADH7ProteinUNIPROT:P40394metabolized byInferred only12 paths12 endpoints
- ADH1CProteinUNIPROT:P00326metabolized byInferred only11 paths11 endpoints
- ADHFE1ProteinUNIPROT:Q8IWW8substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
9 statements
9 statements · 2 reference databases · Subject: S-formylglutathione · Sources: Human-GEM, Rhea
- S-formylglutathione is metabolised by ADH1AProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is metabolised by ADH1CProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is metabolised by ADH5ProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is metabolised by ADH5ProteinHuman-GEM MAR03933Inferred only
- S-formylglutathione is metabolised by ADH6ProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is metabolised by ADH7ProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is a substrate of ADHFE1ProteinHuman-GEM MAR08530Inferred only
- S-formylglutathione is a substrate of ESDProteinRhea RHEA:14961Inferred only
- S-formylglutathione is a substrate of ESDProteinHuman-GEM MAR03937Inferred only
Reactions
7 reactions
S-formylglutathione+proton+NADH(2-)MAM02152c+NAD(+)
Catalysed by ADH5
Reaction pageReversibleBalancedEC 1.1.1.284GO:0005829
Human-GEM MAR03933CC BY 4.0Reference data
S-formylglutathione+waterformic acid+CHEBI:16856+proton
Catalysed by ESD
Reaction pageLeft to rightBalancedEC 3.1.2.12GO:0005829
Human-GEM MAR03937CC BY 4.0Reference data
formaldehyde+CHEBI:16856+NAD(+)S-formylglutathione+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1GO:0005829
Human-GEM MAR08530CC BY 4.0Reference data
MAM02152c+NADP(3-)S-formylglutathione+proton+NADPH(4-)
Catalysed by ADH5
Reaction pageLeft to rightBalancedEC 1.1.1.284GO:0005829
Human-GEM MAR20044CC BY 4.0Reference data
S-formylglutathione+waterformate+glutathione+hydron
Catalysed by ESD
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14961CC BY 4.0Reference data
CHEBI:58758+NADP(3-)S-formylglutathione+NADPH(4-)+hydron
Catalysed by ADH5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19981CC BY 4.0Reference data
CHEBI:58758+NAD(1-)S-formylglutathione+NADH(2-)+hydron
Catalysed by ADH5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19985CC BY 4.0Reference data
Other names
1 name
Resolves to: S-formylglutathione
- Systematic name
- (2S)-2-azaniumyl-5-{[(2R)-1-[(carboxylatomethyl)amino]-3-(formylsulfanyl)-1-oxopropan-2-yl]amino}-5-oxopentanoate