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Proteins/UNIPROT:Q08AH1
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate. Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity)..
Function from UniProtKB (Q08AH1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
36 statements
36 statements · 5 reference databases · Subject: ACSM1 · Sources: Human-GEM, Reactome, Rhea, UniProt, WikiPathways
19 reactions
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00156CC BY 4.0Reference data
ATP+
10 names
Resolves to: ACSM1
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00165CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02120cAMP+CHEBI:27540+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00168CC BY 4.0Reference data
ATP+CHEBI:1146900+heptanoateAMP+MAM02107c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00171CC BY 4.0Reference data
ATP+CHEBI:1146900+octanoateAMP+octanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00174CC BY 4.0Reference data
ATP+CHEBI:1146900+nonanoateAMP+MAM02616c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00177CC BY 4.0Reference data
ATP+CHEBI:1146900+decanoateAMP+decanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00180CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM03117cAMP+diphosphate(3-)+undecanoyl-CoA
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00184CC BY 4.0Reference data
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM1
Reaction pageLeft to rightBalancedEC 6.2.1.2mitochondrial matrix
Human-GEM MAR00742CC BY 4.0Reference data
benzoic acid+ATP(4-)+coenzyme A(4-)benzoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:10132CC BY 4.0Reference data
hexadecanoate+ATP(4-)+coenzyme A(4-)hexadecanoyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A2 or ACSL4 or ACSL3 or ACSL1 or ACSM1 or ACSBG2 or SLC27A3 or SLC27A4 or ACSBG1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalanced
Rhea RHEA:30751CC BY 4.0Reference data
tetradecanoate+ATP(4-)+coenzyme A(4-)tetradecanoyl-CoA+AMP+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:33619CC BY 4.0Reference data