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Proteins/UNIPROT:Q9BYV1
Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure..
Function from UniProtKB (Q9BYV1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
89 statements
89 statements · 9 reference databases · Subject: AGXT2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
21 reactions
2-methyl-3-oxopropanoic acid+L-glutamate(1-)2-oxoglutarate(2-)+(R)-3-aminoisobutyric acid
Reaction pageReversibleBalancedEC 2.6.1.22, 2.6.1.40mitochondrial matrix
Human-GEM MAR03792CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+L-alanine(R)-3-aminoisobutyric acid+pyruvate
Catalysed by AGXT2
8 names
Resolves to: AGXT2
Human-GEM MAR03793CC BY 4.0Reference data
L-alanine+glyoxylic acidglycine+pyruvate
Reaction pageLeft to rightBalancedEC 2.6.1.44mitochondrial matrix
Human-GEM MAR04788CC BY 4.0Reference data
3-oxopropanoate+L-alaninebeta-alanine+pyruvate
Catalysed by AGXT2
Reaction pageRight to leftBalanced
Rhea RHEA:14077CC BY 4.0Reference data
(R)-3-amino-2-methylpropanoate+pyruvate2-methyl-3-oxopropanoate+L-alanine
Catalysed by AGXT2
Reaction pageLeft to rightBalanced
Rhea RHEA:18393CC BY 4.0Reference data
glyoxylate+L-alanineglycine+pyruvate
Reaction pageLeft to rightBalanced
Rhea RHEA:24248CC BY 4.0Reference data
N(omega),N(omega)-dimethyl-L-arginine+pyruvate5-(3,3-dimethylguanidino)-2-oxopentanoate+L-alanine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77303CC BY 4.0Reference data
N(omega),N('omega)-dimethyl-L-arginine+pyruvate5-(3,3'-dimethylguanidino)-2-oxopentanoate+L-alanine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77307CC BY 4.0Reference data
N(omega),N(omega)-dimethyl-L-arginine+glyoxylate5-(3,3-dimethylguanidino)-2-oxopentanoate+glycine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77311CC BY 4.0Reference data
N(omega),N('omega)-dimethyl-L-arginine+glyoxylate5-(3,3'-dimethylguanidino)-2-oxopentanoate+glycine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77315CC BY 4.0Reference data
N(omega)-methyl-L-arginine+pyruvate5-(3-methylguanidino)-2-oxopentanoate+L-alanine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77319CC BY 4.0Reference data
N(omega)-methyl-L-arginine+glyoxylate5-(3-methylguanidino)-2-oxopentanoate+glycine
Catalysed by AGXT2
Reaction pageDirection not assertedBalanced
Rhea RHEA:77323CC BY 4.0Reference data