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Proteins/UNIPROT:Q6P587
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA..
Function from UniProtKB (Q6P587), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 7 reference databases · Subject: FAHD1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
7 reactions
proton+oxaloacetatecarbon dioxide+pyruvate
Catalysed by FAHD1
Reaction pageLeft to rightBalancedEC 4.1.1.112cytosol
Human-GEM MAR11430CC BY 4.0Reference data
proton+oxaloacetatecarbon dioxide+pyruvate
Catalysed by FAHD1
Reaction pageLeft to rightBalancedEC 4.1.1.112mitochondrial matrix
9 names
Resolves to: FAHD1
oxaloacetate+hydronpyruvate+carbon dioxide
Catalysed by ME2 or ME1 or ME3 or FAHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:15641CC BY 4.0Reference data
Catalysed by FAHD2B or FAHD1 or FAHD2A
Reaction pageRight to leftBalanced
Rhea RHEA:16021CC BY 4.0Reference data
acetylpyruvate+wateracetate+pyruvate+hydron
Catalysed by FAHD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:16097CC BY 4.0Reference data
a 3-acylpyruvate+watera carboxylate+pyruvate+hydron
Catalysed by FAHD1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19009CC BY 4.0Reference data
3-fumarylpyruvate+waterfumaric acid+pyruvate+hydron
Catalysed by FAHD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:26168CC BY 4.0Reference data