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Proteins/UNIPROT:Q6QHF9
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs..
Function from UniProtKB (Q6QHF9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
28 statements
28 statements · 6 reference databases · Subject: PAOX · Sources: Bgee, gene ontology, Human-GEM, Reactome, Rhea, UniProt
10 reactions
water+CHEBI:17312+dioxygen3-acetamidopropanal+hydrogen peroxide+spermidine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06958CC BY 4.0Reference data
3 names
Resolves to: PAOX
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06959CC BY 4.0Reference data
water+CHEBI:17927+dioxygen3-acetamidopropanal+hydrogen peroxide+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06961CC BY 4.0Reference data
FAD+water+CHEBI:179273-acetamidopropanal+FADH2+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06962CC BY 4.0Reference data
water+N(1),N(12)-diacetylspermine+dioxygen3-acetamidopropanal+hydrogen peroxide+CHEBI:17927
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06963CC BY 4.0Reference data
FAD+water+N(1),N(12)-diacetylspermine3-acetamidopropanal+FADH2+CHEBI:17927
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06964CC BY 4.0Reference data
FADH2+dioxygenFAD+hydrogen peroxide
Catalysed by ACOX1 or ACOX2 or ACOX3 or DAO or DDO or NOS2 or PAOX or PIPOX or XDH
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR20114CC BY 4.0Reference data
N(1)-acetylspermine+dioxygen+water3-acetamidopropanal+spermidine+hydrogen peroxide
Catalysed by PAOX
Reaction pageDirection not assertedBalanced
Rhea RHEA:25800CC BY 4.0Reference data
N(1)-acetylspermidine+dioxygen+water3-acetamidopropanal+putrescine+hydrogen peroxide
Catalysed by PAOX
Reaction pageDirection not assertedBalanced
Rhea RHEA:25812CC BY 4.0Reference data
N(1),N(12)-diacetylspermine+dioxygen+water3-acetamidopropanal+N(1)-acetylspermidine+hydrogen peroxide
Catalysed by PAOX
Reaction pageDirection not assertedBalanced
Rhea RHEA:25868CC BY 4.0Reference data