prostaglandin H2

1. transport of prostaglandin H2 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

1. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

Catalysed by SLCO2A1inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of GSH and prostaglandin H2 (cytosol to extracellular)

Catalysed by SLCO2A1extracellular space, cytosolOne of 2 routes

1. thromboxane A synthase (12(S)-HHT)

Catalysed by TBXAS1cytosolOne of 2 routes

1. prostaglandin I2 synthase (prostaglandin H2)

Catalysed by PTGISendoplasmic reticulumOne of 2 routes

1. prostaglandin H2 + [thioredoxin]-dithiol = prostaglandin F2alpha + [thioredoxin]-disulfide

Catalysed by PRXL2BOne of 2 routes

1. prostaglandin-D synthase (prostaglandin H2)

Catalysed by HPGDS, PTGDScytosolOne of 3 routes

1. thromboxane A synthase (prostaglandin H2)

Catalysed by TBXAS1endoplasmic reticulumOne of 2 routes

1. prostaglandin E synthase (prostaglandin H2)

Catalysed by PTGES, PTGES3, PTGES2cytosolOne of 3 routes

1. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Catalysed by TBXAS1, CYP2S1, PTGES2

1. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP4F8

1. transport of prostaglandin H2 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin H2 (cytosol to extracellular)
2. transport of glycoursodeoxycholate (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosol