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Proteins/UNIPROT:P08195
Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. Forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acid exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocate neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for the plasma membrane localization, stability, and transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the SLC3A2/SLC7A5 heterodimer is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression..
(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis..
(Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells..
Function from UniProtKB (P08195), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 10 · transported by
10 compounds
10 compounds.
0 reported routes10 assembled routes
180 statements
180 statements · 4 reference databases · Subject: SLC3A2 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
45 reactions
MAM01992e+8water8D-glucose+MAM03622e
Catalysed by SLC3A2 or AMY1B or AMY2A or AMY2B
Reaction pageLeft to rightBalancedEC 3.2.1.1extracellular space
Human-GEM MAR00072CC BY 4.0Reference data
L-cystine+L-glutamate(1-)L-cystine+L-glutamate(1-)
Transported by SLC3A2
7 names
Resolves to: SLC3A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04931CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A2 or SLC7A5 or SLC36A1 or SLC7A7 or SLC7A3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05070CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC43A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05073CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05074CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC6A18
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05076CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05077CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05078CC BY 4.0Reference data
L-seryl residueL-seryl residue
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05079CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05080CC BY 4.0Reference data
L-phenylalanineL-phenylalanine
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC43A1 or SLC7A7 or SLC43A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05082CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05084CC BY 4.0Reference data