Loading the page.
Proteins/UNIPROT:P16219
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains..
Function from UniProtKB (P16219), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
200 statements
200 statements · 8 reference databases · Subject: ACADS · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
27 reactions
6CHEBI:1146900+6FAD+6water+tetradecanoyl-CoA+6NAD(+)7CHEBI:15351+6FADH2+6proton+6NADH(2-)
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00752CC BY 4.0Reference data
2 names
Resolves to: ACADS
6CHEBI:1146900+6FAD+6water+6NAD(+)+MAM02689m6CHEBI:15351+6FADH2+6proton+6NADH(2-)+propionyl-CoA
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00755CC BY 4.0Reference data
7CHEBI:1146900+7FAD+7water+7NAD(+)+palmitoyl-CoA8CHEBI:15351+7FADH2+7proton+7NADH(2-)
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR00756CC BY 4.0Reference data
4CHEBI:1146900+4FAD+4water+4NAD(+)+palmitoyl-CoA4CHEBI:15351+4FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00757CC BY 4.0Reference data
(2E)-hexadecenoyl-CoA+4CHEBI:1146900+3FAD+4water+4NAD(+)4CHEBI:15351+3FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00764CC BY 4.0Reference data
4CHEBI:1146900+3FAD+4water+4NAD(+)+(9Z)-hexadecenoyl-CoA4CHEBI:15351+3FADH2+4proton+4NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00772CC BY 4.0Reference data
5CHEBI:1146900+4FAD+5water+5NAD(+)+(11Z)-octadecenoyl-CoA5CHEBI:15351+4FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00780CC BY 4.0Reference data
5CHEBI:1146900+4FAD+5water+5NAD(+)+oleoyl-CoA5CHEBI:15351+4FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00784CC BY 4.0Reference data
5CHEBI:1146900+3FAD+5water+(9Z,12Z)-octadecadienoyl-CoA+5NAD(+)5CHEBI:15351+3FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00785CC BY 4.0Reference data
(9Z,12Z)-octadecadienoyl-CoA+5CHEBI:1146900+3FAD+5water+5NAD(+)5CHEBI:15351+3FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00788CC BY 4.0Reference data
5CHEBI:1146900+(6Z,9Z,12Z)-octadecatrienoyl-CoA+5water+5NAD(+)+2dioxygen5CHEBI:15351+5proton+2hydrogen peroxide+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00799CC BY 4.0Reference data
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA+5CHEBI:1146900+FAD+5water+5NAD(+)5CHEBI:15351+FADH2+5proton+5NADH(2-)+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00818CC BY 4.0Reference data