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Proteins/UNIPROT:P08842

STS

Protein·UNIPROT:P08842Steryl-sulfatase

Open in the graph

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid..

Function from UniProtKB (P08842), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

recessive X-linked ichthyosis has a germline basis in STSDiseaseGenCC HGNC:11425|MONDO:0010622Inferred only

Statements

83 statements

83 statements · 6 reference databases · Subject: STS · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

STS covaries with GIMAP8ProteinHetionet hetionet:covaries:155038-412Inferred only
LMNTD1 covaries with STSProteinHetionet hetionet:covaries:160492-412Inferred only
STS covaries with TBCDProteinHetionet hetionet:covaries:412-6904Inferred only
TMEM132C covaries with STSProteinHetionet hetionet:covaries:412-92293Inferred only
TMEM132D covaries with STSProteinHetionet hetionet:covaries:121256-412Inferred only
STS interacts with CBLProteinHetionet hetionet:interacts:412-867Inferred only
STS participates in Estrogen metabolismPathwayWikiPathways WP697Inferred only
STS participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
STS participates in Glycosphingolipid catabolismPathwayReactome R-HSA-9840310Inferred only
STS participates in Glycosphingolipid metabolismPathwayReactome R-HSA-1660662Inferred only
STS participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
STS participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only

Show the remaining 71

STS participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
STS participates in Metabolism of steroid hormonesPathwayReactome R-HSA-196071Inferred only
STS participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
STS participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
STS participates in Sphingolipid metabolismPathwayReactome R-HSA-428157Inferred only
STS participates in The activation of arylsulfatasesPathwayReactome R-HSA-1663150Inferred only
STS participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
STS requires the cofactor Ca(2+)CompoundUniProt P08842Inferred only
17alpha-hydroxypregnenolone is a substrate of STSCompoundHuman-GEM MAR02725Inferred only
17alpha-hydroxypregnenolone is a substrate of STSCompoundHuman-GEM MAR02743Inferred only
17alpha-hydroxypregnenolone is a substrate of STSCompoundHuman-GEM MAR02728Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of STSCompoundHuman-GEM MAR02025Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of STSCompoundHuman-GEM MAR03601Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of STSCompoundHuman-GEM MAR03600Inferred only
3,3'-diiodo-L-thyronine is a substrate of STSCompoundHuman-GEM MAR02538Inferred only
3,3'-diiodo-L-thyronine is a substrate of STSCompoundHuman-GEM MAR02536Inferred only
3,3'-diiodo-L-thyronine sulfate is a substrate of STSCompoundHuman-GEM MAR06831Inferred only
3,3'-diiodo-L-thyronine sulfate is a substrate of STSCompoundHuman-GEM MAR02538Inferred only
3,3'-diiodo-L-thyronine sulfate is a substrate of STSCompoundHuman-GEM MAR02536Inferred only
3,3',5-triiodo-L-thyronine sulfate is a substrate of STSCompoundHuman-GEM MAR06839Inferred only
3beta-hydroxyandrost-5-en-17-one is a substrate of STSCompoundRhea RHEA:19873Inferred only
5alpha-dihydrotestosterone sulfate is a substrate of STSCompoundHuman-GEM MAR03600Inferred only
5alpha-dihydrotestosterone sulfate is a substrate of STSCompoundHuman-GEM MAR03601Inferred only
5alpha-dihydrotestosterone sulfate is a substrate of STSCompoundHuman-GEM MAR02025Inferred only
androsterone is a substrate of STSCompoundHuman-GEM MAR03603Inferred only
androsterone is a substrate of STSCompoundHuman-GEM MAR03602Inferred only
androsterone is a substrate of STSCompoundHuman-GEM MAR02020Inferred only
androsterone 3alpha-sulfate is a substrate of STSCompoundHuman-GEM MAR02020Inferred only
androsterone 3alpha-sulfate is a substrate of STSCompoundHuman-GEM MAR03603Inferred only
androsterone 3alpha-sulfate is a substrate of STSCompoundHuman-GEM MAR03602Inferred only
CHEBI:1307929 is a substrate of STSCompoundHuman-GEM MAR02749Inferred only
CHEBI:1307929 is a substrate of STSCompoundHuman-GEM MAR02747Inferred only
cholesterol sulfate is a substrate of STSCompoundHuman-GEM MAR02747Inferred only
cholesterol sulfate is a substrate of STSCompoundHuman-GEM MAR07950Inferred only
cholesterol sulfate is a substrate of STSCompoundHuman-GEM MAR01920Inferred only
cholesterol sulfate is a substrate of STSCompoundHuman-GEM MAR02749Inferred only
dehydroepiandrosterone 3-sulfate is a substrate of STSCompoundRhea RHEA:19873Inferred only
dehydroepiandrosterone 3-sulfate is a substrate of STSCompoundHuman-GEM MAR07952Inferred only
dehydroepiandrosterone 3-sulfate is a substrate of STSCompoundHuman-GEM MAR00794Inferred only
estrone is a substrate of STSCompoundRhea RHEA:31055Inferred only
estrone 3-sulfate is a substrate of STSCompoundRhea RHEA:31055Inferred only
estrone 3-sulfate is a substrate of STSCompoundHuman-GEM MAR07945Inferred only
estrone 3-sulfate is a substrate of STSCompoundHuman-GEM MAR02038Inferred only
glycolithocholate 3-sulfate is a substrate of STSCompoundHuman-GEM MAR01847Inferred only
pregnenolone is a substrate of STSCompoundHuman-GEM MAR02756Inferred only
pregnenolone is a substrate of STSCompoundHuman-GEM MAR02763Inferred only
pregnenolone sulfate is a substrate of STSCompoundHuman-GEM MAR07948Inferred only
pregnenolone sulfate is a substrate of STSCompoundHuman-GEM MAR02763Inferred only
pregnenolone sulfate is a substrate of STSCompoundHuman-GEM MAR01953Inferred only
pregnenolone sulfate is a substrate of STSCompoundHuman-GEM MAR02756Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02728Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02743Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02025Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02747Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02020Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02749Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02756Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02763Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR03602Inferred only
sulfate is a substrate of STSCompoundRhea RHEA:31055Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02536Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02538Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02539Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02589Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02595Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02597Inferred only
sulfate is a substrate of STSCompoundRhea RHEA:19873Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR02725Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR03600Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR03601Inferred only
sulfate is a substrate of STSCompoundHuman-GEM MAR03603Inferred only

Reactions

36 reactions

dehydroepiandrosterone 3-sulfate+water3beta-hydroxyandrost-5-en-17-one+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol
Human-GEM MAR00794CC BY 4.0Reference data
water+MAM02950cchenodeoxycholate+proton+sulfate
Catalysed by STS

Other names

6 names

Resolves to: STS

Also called: ARSC1Arylsulfatase CASCEstrone sulfataseSteroid sulfataseSteryl-sulfate sulfohydrolase

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Left to right

Balanced

EC 3.1.6.2

cytosol

Human-GEM MAR01730CC BY 4.0Reference data

water+glycolithocholate 3-sulfateglycolithocholic acid+proton+sulfate

Catalysed by STS

Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol

Human-GEM MAR01847CC BY 4.0Reference data

cholesterol sulfate+waterCHEBI:1307929+proton+sulfate

Catalysed by STS

Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol

Human-GEM MAR01920CC BY 4.0Reference data

water+pregnenolone sulfateproton+pregnenolone+sulfate

Catalysed by STS

Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol

Human-GEM MAR01953CC BY 4.0Reference data

MAM00407c+water17alpha-hydroxypregnenolone+proton+sulfate

Catalysed by STS

Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol

Human-GEM MAR01963CC BY 4.0Reference data

androsterone 3alpha-sulfate+waterandrosterone+proton+sulfate

Catalysed by STS

Reaction pageReversibleBalancedEC 3.1.6.2cytosol

Human-GEM MAR02020CC BY 4.0Reference data

17beta-hydroxy-5alpha-androstan-3-one+proton+sulfate5alpha-dihydrotestosterone sulfate+water

Catalysed by STS

Reaction pageReversibleBalancedEC 3.1.6.2cytosol

Human-GEM MAR02025CC BY 4.0Reference data

estrone 3-sulfate+waterestrone+proton+sulfate

Catalysed by STS

Reaction pageLeft to rightBalancedEC 3.1.6.1, 3.1.6.2cytosol

Human-GEM MAR02038CC BY 4.0Reference data

3,3'-diiodo-L-thyronine sulfate+water3,3'-diiodo-L-thyronine+proton+sulfate

Catalysed by STS

Reaction pageReversibleBalancedEC 3.1.6.2Golgi apparatus

Human-GEM MAR02536CC BY 4.0Reference data

3,3'-diiodo-L-thyronine sulfate+water3,3'-diiodo-L-thyronine+proton+sulfate

Catalysed by STS

Reaction pageReversibleBalancedEC 3.1.6.2endoplasmic reticulum

Human-GEM MAR02538CC BY 4.0Reference data

MAM00737g+waterMAM00736g+proton+sulfate

Catalysed by STS

Reaction pageReversibleBalancedEC 3.1.6.2Golgi apparatus

Human-GEM MAR02539CC BY 4.0Reference data

Show the remaining 24