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Proteins/UNIPROT:P31641
Mediates sodium- and chloride-dependent transport of taurine, a key amino acid. Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation. Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA)..
Function from UniProtKB (P31641), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
1 row
81 statements
81 statements · 8 reference databases · Subject: SLC6A6 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
chlorine(.)+sodium(1+)+taurinechlorine(.)+sodium(1+)+taurine
Transported by SLC6A6
Reaction pageLeft to rightBalancedEC 2.3.1.86extracellular space, cytosol
Human-GEM MAR02388CC BY 4.0Reference data
Transported by SLC6A6
Reaction pageReversibleBalancedcytosol, peroxisome
3 names
Resolves to: SLC6A6
2sodium(1+)+taurine2sodium(1+)+taurine
Transported by SLC6A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05451CC BY 4.0Reference data
sodium(1+)+taurinesodium(1+)+taurine
Transported by SLC6A6
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR05452CC BY 4.0Reference data
chlorine(.)+2sodium(1+)+taurinechlorine(.)+2sodium(1+)+taurine
Transported by SLC6A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05454CC BY 4.0Reference data
beta-alanine+chlorine(.)+2sodium(1+)beta-alanine+chlorine(.)+2sodium(1+)
Transported by SLC6A6 or SLC6A14
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09601CC BY 4.0Reference data
4-aminobutanoate+chloride+2sodium(1+)4-aminobutanoate+chloride+2sodium(1+)
Transported by SLC6A1 or SLC6A6 or SLC6A11 or SLC6A13
Reaction pageReversibleBalanced
Rhea RHEA:70687CC BY 4.0Reference data
taurine+chloride+2sodium(1+)taurine+chloride+2sodium(1+)
Transported by SLC6A6 or SLC6A11 or SLC6A13
Reaction pageLeft to rightBalanced
Rhea RHEA:71223CC BY 4.0Reference data
hypotaurine+chloride+2sodium(1+)hypotaurine+chloride+2sodium(1+)
Transported by SLC6A1 or SLC6A6 or SLC6A11 or SLC6A13
Reaction pageLeft to rightBalanced
Rhea RHEA:71243CC BY 4.0Reference data
beta-alanine+chloride+2sodium(1+)beta-alanine+chloride+2sodium(1+)
Transported by SLC6A6 or SLC6A11 or SLC6A13 or SLC6A14
Reaction pageLeft to rightBalanced
Rhea RHEA:71247CC BY 4.0Reference data