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Proteins/UNIPROT:Q08AH3
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity)..
Function from UniProtKB (Q08AH3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 6 reference databases · Subject: ACSM2A · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
14 reactions
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00156CC BY 4.0Reference data
ATP+
7 names
Resolves to: ACSM2A
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00165CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02120cAMP+CHEBI:27540+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00168CC BY 4.0Reference data
ATP+CHEBI:1146900+heptanoateAMP+MAM02107c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00171CC BY 4.0Reference data
ATP+CHEBI:1146900+octanoateAMP+octanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00174CC BY 4.0Reference data
ATP+CHEBI:1146900+nonanoateAMP+MAM02616c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00177CC BY 4.0Reference data
ATP+CHEBI:1146900+decanoateAMP+decanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00180CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM03117cAMP+diphosphate(3-)+undecanoyl-CoA
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00184CC BY 4.0Reference data
benzoic acid+ATP(4-)+coenzyme A(4-)benzoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:10132CC BY 4.0Reference data
decanoate+ATP(4-)+coenzyme A(4-)decanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM4 or ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:33627CC BY 4.0Reference data
octanoate+ATP(4-)+coenzyme A(4-)octanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM4 or ACSM1 or ACSM2A or ACSM3 or ACSM2B or ACSF2
Reaction pageLeft to rightBalanced
Rhea RHEA:33631CC BY 4.0Reference data
hexanoate+ATP(4-)+coenzyme A(4-)hexanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM4 or ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:43740CC BY 4.0Reference data