Compound

propanoyl-CoA

Tetranion of propionyl-CoA arising from deprotonation of phosphate and diphosphate functions.

Definition from ChEBI (CHEBI:57392), read 2026-09-23. CC BY 4.0.

CHEBI:57392ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C24H36N7O17P3S
Mass: 819.573 g/mol
Charge: -4
InChIKey: QAQREVBBADEHPA-IEXPHMLFSA-J
SMILES: CCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

14 entities

14 entities reached.

0 reported hops14 assembled from the scaffold

Show the remaining 2

What the reference databases state

Chemical structure

a 2,3-saturated acyl-CoA has the functional parent propanoyl-CoACompoundChEBI CHEBI:65111Inferred only

Statements

41 statements

41 statements · 1 reference database · Subject: propanoyl-CoA · Sources: Rhea

Order

(R)-2-methyl-3-oxopropanoate is converted to propanoyl-CoACompoundRhea RHEA:76623Inferred only
propanoyl-CoA is converted to (R)-methylmalonyl-CoACompoundRhea RHEA:27666Inferred only
(R)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:27666Inferred only
propanoyl-CoA is converted to (S)-2-methyl-3-oxopropanoateCompoundRhea RHEA:31047Inferred only
(S)-2-methyl-3-oxopropanoate is converted to propanoyl-CoACompoundRhea RHEA:31047Inferred only
(S)-2-methyl-3-oxopropanoate is converted to propanoyl-CoACompoundRhea RHEA:76627Inferred only
(S)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:61340Inferred only
propanoyl-CoA is converted to (S)-methylmalonyl-CoACompoundRhea RHEA:23720Inferred only
propanoyl-CoA is converted to (S)-methylmalonyl-CoACompoundRhea RHEA:21396Inferred only
(S)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:21396Inferred only
2-methyl-3-oxobutanoyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:30719Inferred only
propanoyl-CoA is converted to 2-methyl-3-oxobutanoyl-CoACompoundRhea RHEA:30719Inferred only

Show the remaining 29

2-methyl-3-oxopropanoate is converted to propanoyl-CoACompoundRhea RHEA:20804Inferred only
propanoyl-CoA is converted to 2-oxobutanoateCompoundRhea RHEA:33223Inferred only
2-oxobutanoate is converted to propanoyl-CoACompoundRhea RHEA:33223Inferred only
propanoyl-CoA is converted to acryloyl-CoACompoundRhea RHEA:34471Inferred only
acryloyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:34471Inferred only
acryloyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:26454Inferred only
propanoyl-CoA is converted to acryloyl-CoACompoundRhea RHEA:26454Inferred only
propanoyl-CoA is converted to propanalCompoundRhea RHEA:36027Inferred only
propanal is converted to propanoyl-CoACompoundRhea RHEA:36027Inferred only
propanoate is converted to propanoyl-CoACompoundRhea RHEA:20373Inferred only
propanoyl-CoA is converted to propanoateCompoundRhea RHEA:40103Inferred only
propanoyl-CoA is converted to propanoateCompoundRhea RHEA:29843Inferred only
propanoate is converted to propanoyl-CoACompoundRhea RHEA:29843Inferred only
propanoyl-CoA is converted to propanoyl-4'-phosphopantetheineCompoundRhea RHEA:67464Inferred only
propanoyl-CoA is a substrate of ACAA2ProteinRhea RHEA:40103Inferred only
propanoyl-CoA is a substrate of ACAD8ProteinRhea RHEA:31287Inferred only
propanoyl-CoA is a substrate of ACAT1ProteinRhea RHEA:30719Inferred only
propanoyl-CoA is a substrate of ACOT8ProteinRhea RHEA:40103Inferred only
propanoyl-CoA is a substrate of ACOT9ProteinRhea RHEA:40103Inferred only
propanoyl-CoA is a substrate of CLYBLProteinRhea RHEA:47628Inferred only
propanoyl-CoA is a substrate of CRATProteinRhea RHEA:44976Inferred only
propanoyl-CoA is a substrate of EP300ProteinRhea RHEA:54020Inferred only
propanoyl-CoA is a substrate of KAT2AProteinRhea RHEA:54020Inferred only
propanoyl-CoA is a substrate of KAT8ProteinRhea RHEA:54020Inferred only
propanoyl-CoA is a substrate of NUDT19ProteinRhea RHEA:67464Inferred only
propanoyl-CoA is a substrate of NUDT7ProteinRhea RHEA:67464Inferred only
propanoyl-CoA is a substrate of NUDT8ProteinRhea RHEA:67464Inferred only
propanoyl-CoA is a substrate of PCCAProteinRhea RHEA:23720Inferred only
propanoyl-CoA is a substrate of PCCBProteinRhea RHEA:23720Inferred only

Reactions

44 reactions

4,8,12-trimethyltridecanoyl-CoA+propanoyl-CoA3-oxopristanoyl-CoA+coenzyme A(4-)
Catalysed by SCP2
Reaction pageRight to leftBalanced
Rhea RHEA:10408CC BY 4.0Reference data
choloyl-CoA+propanoyl-CoA3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA+coenzyme A(4-)
Catalysed by SCP2
Reaction pageRight to leftBalanced
Rhea RHEA:16865CC BY 4.0Reference data
propanoyl-CoA+glyoxylate+waterCHEBI:11596+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19185CC BY 4.0Reference data
propanoate+ATP(4-)+coenzyme A(4-)propanoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM3 or ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalanced
Rhea RHEA:20373CC BY 4.0Reference data
(S)-methylmalonyl-CoA+pyruvatepropanoyl-CoA+oxaloacetate
Reaction pageDirection not assertedBalanced
Rhea RHEA:20764CC BY 4.0Reference data
2-methyl-3-oxopropanoate+NAD(1-)+coenzyme A(4-)+waterpropanoyl-CoA+hydrogencarbonate+NADH(2-)+hydron
Catalysed by ALDH6A1
Reaction pageLeft to rightBalanced
Rhea RHEA:20804CC BY 4.0Reference data
(S)-methylmalonyl-CoA+sodium(1+)+hydronpropanoyl-CoA+sodium(1+)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:21396CC BY 4.0Reference data
6(S)-methylmalonyl-CoA+propanoyl-CoA+6NADPH(4-)+12hydronCHEBI:16089+6carbon dioxide+6NADP(3-)+7coenzyme A(4-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:23068CC BY 4.0Reference data
propanoate+acetyl-CoApropanoyl-CoA+acetate
Reaction pageDirection not assertedBalanced
Rhea RHEA:23520CC BY 4.0Reference data
propanoyl-CoA+hydrogencarbonate+ATP(4-)(S)-methylmalonyl-CoA+ADP(3-)+hydrogenphosphate+hydron
Catalysed by PCCA or PCCB
Reaction pageLeft to rightBalanced
Rhea RHEA:23720CC BY 4.0Reference data
propanoyl-CoA+oxaloacetate+waterCHEBI:58853+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:23780CC BY 4.0Reference data
propanoyl-CoA+NADP(3-)acryloyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:26454CC BY 4.0Reference data

Show the remaining 32

Other names

5 names

Resolves to: propanoyl-CoA

Also called: propanoyl-CoA tetraanionpropanoyl-Coenzyme A(4-)propanoyl-Coenzyme A(4−)propionyl-CoA
Systematic name: 3'-phosphonatoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} diphosphate)