Compound

(R)-S-lactoylglutathione

Conjugate base of (R)-S-lactoylglutathione.

Definition from ChEBI (CHEBI:57474), read 2026-09-23. CC BY 4.0.

CHEBI:57474ChEBI

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Structure

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A generated conformer of (R)-S-lactoylglutathione — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C13H20N3O8S
Mass: 378.383 g/mol
Charge: -1
InChIKey: VDYDCVUWILIYQF-CSMHCCOUSA-M
SMILES: C[C@@H](O)C(=O)SC[C@H](NC(=O)CC[C@H]([NH3+])C(=O)[O-])C(=O)NCC(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: (R)-S-lactoylglutathione · Sources: Human-GEM, Rhea

Order

(R)-S-lactoylglutathione is metabolised by ADH1AProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is metabolised by ADH1CProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is metabolised by ADH4ProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is metabolised by ADH5ProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is metabolised by ADH6ProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is metabolised by ADH7ProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is a substrate of ADHFE1ProteinHuman-GEM MAR08502Inferred only
(R)-S-lactoylglutathione is a substrate of HAGHProteinHuman-GEM MAR03857Inferred only
(R)-S-lactoylglutathione is a substrate of HAGHProteinHuman-GEM MAR08511Inferred only
(R)-S-lactoylglutathione is a substrate of HAGHProteinRhea RHEA:25245Inferred only
(R)-S-lactoylglutathione is a substrate of HAGHLProteinHuman-GEM MAR03857Inferred only
(R)-S-lactoylglutathione is a substrate of HAGHLProteinHuman-GEM MAR08511Inferred only

Reactions

7 reactions

CHEBI:16856+methylglyoxal(R)-S-lactoylglutathione
Catalysed by GLO1 or GLOD4
Reaction pageLeft to rightBalancedEC 4.4.1.5cytosol
Human-GEM MAR03853CC BY 4.0Reference data
(R)-S-lactoylglutathione+water(R)-lactic acid+CHEBI:16856+proton
Catalysed by HAGH or HAGHL
Reaction pageLeft to rightBalancedEC 3.1.2.6cytosol
Human-GEM MAR03857CC BY 4.0Reference data
(R)-S-lactoylglutathione+proton+NADH(2-)(R)-lactaldehyde+CHEBI:16856+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR08502CC BY 4.0Reference data
(R)-S-lactoylglutathione(R)-S-lactoylglutathione
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR08510CC BY 4.0Reference data
(R)-S-lactoylglutathione+water(R)-lactic acid+CHEBI:16856+proton
Catalysed by HAGH or HAGHL
Reaction pageLeft to rightBalancedEC 3.1.2.6mitochondrial matrix
Human-GEM MAR08511CC BY 4.0Reference data
(R)-S-lactoylglutathionemethylglyoxal+glutathione
Catalysed by GLO1
Reaction pageRight to leftBalanced
Rhea RHEA:19069CC BY 4.0Reference data
(R)-S-lactoylglutathione+water(R)-lactate+glutathione+hydron
Catalysed by HAGH
Reaction pageLeft to rightBalanced
Rhea RHEA:25245CC BY 4.0Reference data

Other names

3 names

Resolves to: (R)-S-lactoylglutathione

Also called: (R)-S-lactoylglutathionate anion
Systematic name: S-[(2R)-2-hydroxypropanoyl]-gamma-L-glutamyl-L-cysteinylglycinateS-[(2R)-2-hydroxypropanoyl]-γ-L-glutamyl-L-cysteinylglycinate