Compound
7,8-dihydrofolate
Dianion of dihydrofolic acid arising from deprotonation of both carboxylic acid functions.
Definition from ChEBI (CHEBI:57451), read 2026-09-23. CC BY 4.0.
Structure
No depiction stored
Loading the model…
- Class
- Organic compound, anion
- Formula
- C19H19N7O6
- Mass
- 441.404 g/mol
- Charge
- -2
- InChIKey
- OZRNSSUDZOLUSN-LBPRGKRZSA-L
- SMILES
- Nc1nc2c(c(=O)n1)N=C(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
- DHFRProteinUNIPROT:P00374substrate ofInferred only186 paths31 endpoints
- folic acidCompoundCHEBI:27470converted toInferred only57 paths16 endpoints
- DHFR2ProteinUNIPROT:Q86XF0substrate ofInferred only30 paths5 endpoints
- FPGSProteinUNIPROT:Q05932substrate ofInferred only4 paths2 endpoints
What the reference databases state
Statements
28 statements
28 statements · 2 reference databases · Subject: 7,8-dihydrofolate · Sources: Human-GEM, Rhea
- 7,8-dihydrofolate is converted to (6S)-5,6,7,8-tetrahydrofolateCompoundRhea RHEA:15009Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04332Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04335Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04333Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04332Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04335Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04333Inferred only
- folic acid is converted to 7,8-dihydrofolateCompoundRhea RHEA:31103Inferred only
- 7,8-dihydrofolate is converted to folic acidCompoundHuman-GEM MAR04654Inferred only
- 7,8-dihydrofolate is converted to folic acidCompoundHuman-GEM MAR04655Inferred only
- 7,8-dihydrofolate is converted to folic acidCompoundRhea RHEA:31103Inferred only
- folic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04654Inferred only
Show the remaining 16
- folic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04655Inferred only
- folic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04656Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinHuman-GEM MAR04655Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinHuman-GEM MAR04335Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinHuman-GEM MAR04654Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinHuman-GEM MAR04333Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinHuman-GEM MAR04332Inferred only
- 7,8-dihydrofolate is a substrate of DHFRProteinRhea RHEA:15009Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinHuman-GEM MAR04333Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinHuman-GEM MAR04335Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinHuman-GEM MAR04332Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinHuman-GEM MAR04654Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinHuman-GEM MAR04655Inferred only
- 7,8-dihydrofolate is a substrate of DHFR2ProteinRhea RHEA:15009Inferred only
- 7,8-dihydrofolate is a substrate of FPGSProteinHuman-GEM MAR08105Inferred only
- 7,8-dihydrofolate is a substrate of FPGSProteinHuman-GEM MAR08112Inferred only
Reactions
23 reactions
7,8-dihydrofolate7,8-dihydrofolate
Reaction pageReversibleBalancedEC 2.8.2.2cytosol, mitochondrial matrix
Human-GEM MAR00229CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADH(2-)NAD(+)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04332CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04333CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3mitochondrial matrix
Human-GEM MAR04335CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+dUMP7,8-dihydrofolate+dTMP
Catalysed by TYMS
Reaction pageLeft to rightBalancedEC 2.1.1.45cytosol
Human-GEM MAR04644CC BY 4.0Reference data
folic acid+NADH(2-)7,8-dihydrofolate+NAD(+)
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04654CC BY 4.0Reference data
folic acid+NADPH(4-)7,8-dihydrofolate+NADP(3-)
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04655CC BY 4.0Reference data
folic acid+NADPH(4-)7,8-dihydrofolate+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.5.1.3mitochondrial matrix
Human-GEM MAR04656CC BY 4.0Reference data
4ATP+7,8-dihydrofolate+4L-glutamate(1-)4ADP+4proton+MAM02691c+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08105CC BY 4.0Reference data
4ATP+7,8-dihydrofolate+4L-glutamate(1-)4ADP+4proton+MAM02691m+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17mitochondrial matrix
Human-GEM MAR08112CC BY 4.0Reference data
4water+MAM02691e7,8-dihydrofolate+4L-glutamate(1-)
Catalysed by GGH
Reaction pageLeft to rightBalancedEC 3.4.19.9extracellular space
Human-GEM MAR08129CC BY 4.0Reference data
4water+MAM02691l7,8-dihydrofolate+4L-glutamate(1-)
Catalysed by GGH
Reaction pageLeft to rightBalancedEC 3.4.19.9lysosome
Human-GEM MAR08130CC BY 4.0Reference data
Other names
2 names
Resolves to: 7,8-dihydrofolate
- Also called
- dihydrofolate dianion
- Systematic name
- N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate