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Proteins/UNIPROT:Q8TCT1
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity)..
Function from UniProtKB (Q8TCT1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
46 statements
46 statements · 6 reference databases · Subject: PHOSPHO1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt
4 reactions
O-phosphoethanolamine+waterethanolamine+phosphate(3-)
Catalysed by PHOSPHO1
Reaction pageLeft to rightBalancedEC 3.1.3.75cytosol
Human-GEM MAR00649CC BY 4.0Reference data
water+CHEBI:18132choline+phosphate(3-)
Catalysed by PHOSPHO1
Reaction pageLeft to rightBalancedEC 3.1.3.75cytosol
1 name
Resolves to: PHOSPHO1
phosphocholine+watercholine+hydrogenphosphate
Catalysed by PHOSPHO1
Reaction pageDirection not assertedBalanced
Rhea RHEA:10492CC BY 4.0Reference data
phosphoethanolamine+waterethanolamine+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:16089CC BY 4.0Reference data