Compound
2-oxoadipate
Dianion of 2-oxoadipic acid arising from deprotonation of both carboxylic acid groups.
Definition from ChEBI (CHEBI:57499), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C6H6O5
- Mass
- 158.109 g/mol
- Charge
- -2
- InChIKey
- FGSBNBBHOZHUBO-UHFFFAOYSA-L
- SMILES
- O=C([O-])CCCC(=O)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
13 statements
13 statements · 2 reference databases · Subject: 2-oxoadipate · Sources: Human-GEM, Rhea
- 2-oxoadipate is converted to (R)-2-hydroxyglutarateCompoundRhea RHEA:71787Inferred only
- (R)-2-hydroxyglutarate is converted to 2-oxoadipateCompoundRhea RHEA:71787Inferred only
- 2-oxoadipate is converted to glutaryl-CoACompoundRhea RHEA:30795Inferred only
- glutaryl-CoA is converted to 2-oxoadipateCompoundRhea RHEA:30795Inferred only
- L-2-aminoadipate is converted to 2-oxoadipateCompoundRhea RHEA:12601Inferred only
- 2-oxoadipate is a substrate of AADATProteinRhea RHEA:70047Inferred only
- 2-oxoadipate is a substrate of AADATProteinHuman-GEM MAR04597Inferred only
- 2-oxoadipate is a substrate of AADATProteinHuman-GEM MAR04596Inferred only
- 2-oxoadipate is a substrate of DHTKD1ProteinRhea RHEA:69576Inferred only
- 2-oxoadipate is a substrate of DHTKD1ProteinHuman-GEM MAR20173Inferred only
- 2-oxoadipate is a substrate of OGDHProteinHuman-GEM MAR20173Inferred only
- 2-oxoadipate is transported by SLC25A21ProteinHuman-GEM MAR04237Inferred only
Show the remaining 1
- 2-oxoadipate is transported by SLC25A21ProteinRhea RHEA:71739Inferred only
Reactions
19 reactions
MAM00634c+water+NADPH(4-)2-oxoadipate+NADP(3-)+ammonium
Reaction pageLeft to rightBalancedEC 1.5.1.-cytosol
Human-GEM MAR04235CC BY 4.0Reference data
2-oxoadipate+2-oxoglutarate(2-)2-oxoadipate+2-oxoglutarate(2-)
Transported by SLC25A21
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04237CC BY 4.0Reference data
2-oxoadipate+L-glutamate(1-)2-oxoglutarate(2-)+MAM02322c
Catalysed by AADAT
Reaction pageReversibleBalancedEC 2.6.1.39cytosol
Human-GEM MAR04596CC BY 4.0Reference data
2-oxoadipate+L-glutamate(1-)2-oxoglutarate(2-)+MAM02322m
Catalysed by AADAT
Reaction pageReversibleBalancedEC 2.6.1.39mitochondrial matrix
Human-GEM MAR04597CC BY 4.0Reference data
2-oxoadipate+proton+NADH(2-)NAD(+)+MAM03410c
Reaction pageReversibleBalancedEC 1.1.1.172cytosol
Human-GEM MAR09935CC BY 4.0Reference data
2-oxoadipate+2-oxoglutarate(2-)2-oxoadipate+2-oxoglutarate(2-)
Reaction pageReversibleBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09967CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10183CC BY 4.0Reference data
2-oxoadipate+proton+thiamine(1+) diphosphatecarbon dioxide+MAM20077m
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.-mitochondrial matrix
Human-GEM MAR20173CC BY 4.0Reference data
CHEBI:15404+NAD(1-)2-oxoadipate+carbon dioxide+NADH(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:11900CC BY 4.0Reference data
L-2-aminoadipate+2-oxoglutarate(2-)2-oxoadipate+L-glutamate(1-)
Catalysed by AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:12601CC BY 4.0Reference data
CHEBI:57987+NAD(1-)2-oxoadipate+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:14793CC BY 4.0Reference data
2-oxoadipate+NAD(1-)+coenzyme A(4-)glutaryl-CoA+carbon dioxide+NADH(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:30795CC BY 4.0Reference data
Other names
6 names
Resolves to: 2-oxoadipate
- Also called
- 2-keto-adipate2-ketoadipate2-oxohexanedioic acid dianionalpha-ketoadipateα-ketoadipate
- Systematic name
- 2-oxohexanedioate