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Proteins/UNIPROT:Q86XF0
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR..
Function from UniProtKB (Q86XF0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
19 statements
19 statements · 6 reference databases · Subject: DHFR2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
7,8-dihydrofolate+proton+NADH(2-)NAD(+)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04332CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Catalysed by
4 names
Resolves to: DHFR2
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04333CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3mitochondrial matrix
Human-GEM MAR04335CC BY 4.0Reference data
folic acid+NADH(2-)7,8-dihydrofolate+NAD(+)
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04654CC BY 4.0Reference data
folic acid+NADPH(4-)7,8-dihydrofolate+NADP(3-)
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04655CC BY 4.0Reference data
folic acid+NADPH(4-)7,8-dihydrofolate+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.5.1.3mitochondrial matrix
Human-GEM MAR04656CC BY 4.0Reference data
(6S)-5,6,7,8-tetrahydrofolate+NADP(3-)7,8-dihydrofolate+NADPH(4-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:15009CC BY 4.0Reference data